Showing papers in "Biomaterials in 2014"

TL;DR: It is shown that exosomes modified by targeting ligands can be used therapeutically for the delivery of Dox to tumor tissue in BALB/c nude mice, thus having great potential value for clinical applications.

TL;DR: The use and optimization of VA-086 as a photo-initiator with enhanced biocompatibility compared to the conventional Irgacure 2959 is proposed and Mechanically stable cell-laden gelatin methacrylamide scaffolds with high cell viability (>97%) could be printed.

TL;DR: It is shown that primary human M1 macrophages secrete the highest levels of potent angiogenic stimulators including VEGF, a chemoattractant for stabilizing pericytes and also promote anastomosis of sprouting endothelial cells in vitro.

TL;DR: Recent works on the design and development of nano-sized delivery systems for curcumin, including liposomes, polymeric nanoparticles and micelles, conjugates, peptide carriers, cyclodextrins, solid dispersions, lipid nanoparticlesand emulsions are summarized.

TL;DR: This study demonstrates optimization of material parameters for 3D printed calcium phosphate scaffolds and enhancement of material properties by volumetric collagen incorporation via inkjet printing.

TL;DR: Recent exciting developments in click hydrogels, microgels and nanogels, as well as their biomedical applications such as controlled protein and drug release, tissue engineering, and regenerative medicine are presented and discussed.

TL;DR: New attempts in the design of template (or scaffold) materials are delineated, especially in the context of biocompatibility, the choice and handling of support cells, and growth factor release systems, to create a self-consistent coordinated system with a close proximity to the regenerative microenvironment of the peripheral nervous system.

TL;DR: GQD possesses no obvious in vitro and in vivo toxicity, even under multi-dosing situation, as well as wide chemical adaptability and high adsorption capacity.

TL;DR: A methodology using 3D bio-printing technology to create a functional in vitro vascular channel with perfused open lumen using only cells and biological matrices to investigate fundamental mechanisms of vascular remodeling with extracellular matrix and maturation process under 3D flow condition.

TL;DR: The obtained data suggest that co-delivery of DOX and miR-34a could achieve synergistic effects on tumor suppression and nanosystem-based co-Delivery of tumor suppressive miRNAs and chemotherapeutic agents may be a promising combined therapeutic strategy for enhanced anti-tumor therapy.

TL;DR: This study provides novel 3D in vitro quantitative data on extravasation and micrometastasis generation of breast cancer cells within a bone-like microenvironment and demonstrates the potential value of microfluidic systems to better understand cancer biology and screen for new therapeutics.

TL;DR: In this paper, a macroporous electrospun polycaprolactone (PCL) scaffolds with thicker fibers (5-6μm) and larger pores (∼30 μm) were fabricated to enhance the vascular regeneration and remodeling process.

TL;DR: The results indicate that Ag2S QDs are promising NIR-II fluorescent nanoprobes that could be useful in surgical treatments such as sentinel lymph node (SLN) dissection as well in assessment of blood supply in tissues and organs and screening of anti-angiogenic drugs.

TL;DR: This work reports a systematic fall in the heating efficiency for nanomaterials associated with tumour cells, and correlated with the magnetic characterization of the samples, demonstrating a complete inhibition of the Brownian relaxation in cellular conditions.

TL;DR: It is concluded that electroactive PANI and its derivatives show great promise in eliciting favorable responses from various cell lines that respond to electrical stimuli, and are therefore effective biomaterials for the engineering of electrically responsive biological tissues and organs.

TL;DR: Electrochemical polarization and ion release measurements suggest that the excellent osteogenic activity and antibacterial ability of the Zn/Ag co-implanted titanium are related to the synergistic effect resulting from the long-range interactions of the released Zn ions and short-range interaction of the embedded Ag NPs.

TL;DR: The results indicate that CNS glial cells respond to mechanical cues, and suggest that adapting the surface stiffness of neural implants to that of nervous tissue could minimize adverse reactions and improve biocompatibility.

TL;DR: Electrochemically produced graphene quantum dots (GQD), a new class of carbon nanoparticles, generate reactive oxygen species when photoexcited, and kill two strains of pathogenic bacteria, methicillin-resistant Staphylococcus aureus and Escherichia coli.

TL;DR: A class of injectable, biodegradable, and non-toxic hydrogel derived from N, O-carboxymethyl chitosan (NOCC) and aldehyde hyaluronic acid (A-HA), without requirement of any chemical linkers or radiant light sources is reported.

TL;DR: The potential for using MNA-loaded PCL/gelatin electrospun membranes as anti-infective GTR/GBR membranes to optimize clinical application of GTR-GBR strategies is indicated.

TL;DR: A dual process encompassing anodization and silver plasma immersion ion implantation (Ag PIII) is utilized to produce titania nanotubes (TiO₂-NTs) containing Ag at different sites and depths and the technique and resulting materials have large potential in dental implants.

TL;DR: The NT-Ag2O arrays can effectively kill Escherichia coli and Staphylococcus aureus even after immersion for 28 days, demonstrating the long lasting antibacterial ability.

TL;DR: In vitro cytotoxicity assays against A549 human lung adenocarcinoma cell line demonstrated that the DOX + PTX co-delivered nanoparticles (Co-NPs) exhibited synergistic effect in inducing cancer cell apoptosis, indicating this co- delivery system with different functional antitumor drugs provides the clinical potential in cancer therapy.

TL;DR: It is suggested that UCNPs with well-designed surface engineering could serve as a multifunctional nano-platform promising in cancer theranostics, by obtaining UCNP@BSA nanoparticles with great solubility and stability in physiological environments.

TL;DR: Self-assembled nanoparticles which can selectively release the hydrophobic agents under hypoxic conditions might have a potential as nanocarriers for drug delivery to treat hypoxia-associated diseases.

TL;DR: A pH-responsive charge-reversal polyelectrolyte and integrin αⅤβ3 mono-antibody functionalized graphene oxide (GO) complex is constituted as a nanocarrier for targeted delivery and controlled release of DOX into cancer cells, likely to be an available candidate for targeted drug delivery in tumor therapy.

TL;DR: Interestingly, AgNPs induced morphological and biochemical markers of autophagy in NIH 3T3 cells and induced autophagosome formation, as evidenced by transmission electron microscopic analysis, the formation of microtubule-associated protein-1 light chain-3 (LC3) puncta and the expression of LC3-II protein.

TL;DR: Through a one-time treatment of NIR laser irradiation after intravenous injection of Au@PB NPs, 100 mm(3) sized tumors in nude mice could be completely ablated without recurrence.

TL;DR: Cell-adhesive and degradable gelatin scaffolds that could be injected through a conventional needle while maintaining a predefined geometry and architecture are created and suggest that gelatin cryogels could serve as a cell-responsive platform for biomaterial-based therapy.

TL;DR: Compared to the single photodynamic therapy (PDT) or photothermal therapy (PTT), the RB-GNRs with combined PDT-PTT capabilities provide better therapeutic effects against oral cancer and have large potential in cancer treatment.