Hui Ying Lim

TL;DR: A novel β cell-based high-throughput screening assay to identify small molecules that protect β cells against ER stress-induced cell death shows that the compounds promote β cell survival by reducing the expression of key genes of the unfolded protein response and apoptosis, thus alleviating ER stress.

TL;DR: It is shown that 9c protects β-cells by alleviating ER stress through the suppression of the induction of key genes of the unfolded protein response and apoptosis, and restores the ER stress-impaired glucose-stimulated insulin secretion response and survival in primary human islet β- cells.

TL;DR: High-throughput screening is used to identify a series of 1,2,3-triazole amide derivatives that inhibit ER stress-induced CHOP-luciferase reporter activity and shows that compounds with an N,1-diphenyl-5-methyl-1H-1,2-3-Triazole-4-carboxamide backbone potently protect β cell against ER stress.

TL;DR: 5-nitrofuran-2-amide derivatives are identified as small molecule activators of CHOP expression that induced apoptosis in triple negative breast cancer (TNBC) cells.

TL;DR: A comparative study was conducted to evaluate the physicochemical (colour, water activity, pH, water solubility, proximate, mineral, amino acid, and fatty acid composition) and microbiological qualities of Bombyx mori silkworm powder produced from two developmental stages (larvae and pupae). Silkworm pupae powder (SPP) had significantly higher (p<0.05) lightness (L*) and yellowness (b*) values than silkworm larval powder (SLP) as discussed by the authors .