Hui Zhang

TL;DR: Before a safe and effective vaccine becomes available, healthcare professionals remain susceptible to covid-19 and healthcare systems must give priority to the procurement and distribution of personal protective equipment, and provide adequate training to healthcare professionals in its use.

TL;DR: The results suggest that gastric cancer cells inhibit CD8 T-cell metabolism through CD155/TIGIT signaling, which inhibits CD8T-cell effector functions, resulting in hyporesponsive antitumor immunity.

TL;DR: It is found that in patients with the autoimmune vasculitis giant cell arteritis, antigen-presenting cells provide insufficient negative signaling; unleashing highly activated T cells to infiltrate and damage the walls of large arteries; thus, immunoinhibitory signals protect large arteries against inflammatory attack and checkpoint activation may be a suitable strategy to treat autoimmune Vasculitis.

TL;DR: Activation of the P2X7 signaling pathway accelerates lupus nephritis in murine LN by activating the NLRP3/ASC/caspase 1 inflammasome, resulting in increased IL-1β production and enhanced Th17 cell polarization.

TL;DR: It is suggested that dual inhibition of NLRP3 inflammasome and NF-κB activation using Bay11-7082 or its analogues may be a promising therapeutic strategy for preventing the progression of LN.