Huijie Jiang

TL;DR: The findings demonstrate that the protective effect of GSPE on Pb-induced lung injury arises from activation of the AMPK/Nrf2/p62 signaling pathway, thus providing a new approach for treatment of Pb intoxication.

TL;DR: Dietary GSPE attenuated PbAc-induced liver injury in rats via an integrated mechanism associated with the miRNA153 and AKT/glycogen synthase kinase 3 beta/Fyn-mediated Nrf2 activation.

TL;DR: Sulforaphane prevents K2Cr2O7-induced lung toxicity in rats through enhancing Nrf2-mediated exogenous antioxidant defenses via activation of the Akt/GSK-3β/Fyn signaling pathway and demonstrates that SFN may be a novel natural substance to cure Cr-induced pulmonary toxicity.

TL;DR: This study identifies for the first time that Pb-induced oxidative stress in rat kidney is attenuated by GSPE treatment via activating Nrf2 signaling pathway and suppressing miR153 and GSK-3β.

TL;DR: Astaxanthin treatment attenuates inflammation response in the liver after the cessation of chronic arsenic exposure via inhibition of cytokine-mediated cell-cell interactions, and demonstrates that daily ingestion of natural astaxanthIn might be a potential and beneficial candidate for the treatment of liver damage after the ceased of chronic exposure to sodium arsenite.