H
Huiyun Liang
Researcher at University of Texas Health Science Center at San Antonio
Publications - 17
Citations - 1654
Huiyun Liang is an academic researcher from University of Texas Health Science Center at San Antonio. The author has contributed to research in topics: Irofulven & Apoptosis. The author has an hindex of 13, co-authored 17 publications receiving 1414 citations. Previous affiliations of Huiyun Liang include Tel Aviv University & University of Texas at San Antonio.
Papers
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Journal ArticleDOI
PGC-1α: a key regulator of energy metabolism
Huiyun Liang,Walter F. Ward +1 more
TL;DR: It is highly likely that PGC-1alpha is intimately involved in disorders such as obesity, diabetes, and cardiomyopathy, which makes it an inviting target for pharmacological intervention in the treatment of obesity and Type 2 diabetes.
Journal ArticleDOI
The in vivo gene expression signature of oxidative stress
Eun Soo Han,Florian L. Muller,Viviana I. Pérez,Wenbo Qi,Huiyun Liang,Liang Xi,Chunxiao Fu,Erin Doyle,Morgen Hickey,John E. Cornell,Charles J. Epstein,L. Jackson Roberts,Holly Van Remmen,Holly Van Remmen,Arlan Richardson,Arlan Richardson +15 more
TL;DR: In this paper, the authors measured oxidative stress parameters and gene expression alterations (Affymetrix arrays) in the presence of elevated oxidative stress in vivo, and found that higher organisms respond to elevated oxidative stress in higher organisms.
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Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1
Meilian Liu,Meilian Liu,Juli Bai,Juli Bai,Sijia He,Sijia He,Ricardo Villarreal,Derong Hu,Chuntao Zhang,Chuntao Zhang,Xin Yang,Huiyun Liang,Thomas J. Slaga,Yonghao Yu,Zhiguang Zhou,John Blenis,Philipp E. Scherer,Lily Q. Dong,Feng Liu,Feng Liu +19 more
TL;DR: This study has uncovered a unique feedback mechanism regulating mTORC1 signaling in adipose tissues and identified Grb10 as a key regulator of adiposity, thermogenesis, and energy expenditure.
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Whole body overexpression of PGC-1α has opposite effects on hepatic and muscle insulin sensitivity
Huiyun Liang,Bogdan Balas,Puntip Tantiwong,John J. Dubé,Bret H. Goodpaster,Robert M. O'Doherty,Ralph A. DeFronzo,Arlan Richardson,Nicolas Musi,Walter F. Ward +9 more
TL;DR: The dichotomous effect of P GC-1alpha overexpression in liver and muscle suggests that PGC-1 alpha is a fuel gauge that couples energy demands (muscle) with the corresponding fuel supply (liver) under conditions of physiological stress, and increased hepatic glucose production may help sustain glucose utilization in peripheral tissues.
Journal ArticleDOI
PGC‐1α protects neurons and alters disease progression in an amyotrophic lateral sclerosis mouse model
Huiyun Liang,Walter F. Ward,Youngmok C. Jang,Arunabh Bhattacharya,Arunabh Bhattacharya,Alex Bokov,Yan Li,Amanda L. Jernigan,Arlan Richardson,Arlan Richardson,Holly Van Remmen,Holly Van Remmen +11 more
TL;DR: A sustained level of excitatory amino acid transporter protein 2 (EAAT2) in astrocytes of the PGC‐1α/G93A DL mice may contribute to neuronal protection.