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Amanda L. Jernigan
Researcher at University of Texas Health Science Center at San Antonio
Publications - 10
Citations - 422
Amanda L. Jernigan is an academic researcher from University of Texas Health Science Center at San Antonio. The author has contributed to research in topics: Skeletal muscle & Amyotrophic lateral sclerosis. The author has an hindex of 9, co-authored 10 publications receiving 385 citations. Previous affiliations of Amanda L. Jernigan include University of Texas at San Antonio.
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Journal ArticleDOI
Lack of methionine sulfoxide reductase A in mice increases sensitivity to oxidative stress but does not diminish life span
Adam B. Salmon,Viviana I. Pérez,Alex Bokov,Amanda L. Jernigan,Geumsoo Kim,Hang Zhao,Rodney L. Levine,Arlan Richardson,Arlan Richardson +8 more
TL;DR: The results show that MsrA regulates sensitivity to oxidative stress in mice but has no effect on aging, as determined by life span, which is in contrast to previous reports.
Journal ArticleDOI
PGC‐1α protects neurons and alters disease progression in an amyotrophic lateral sclerosis mouse model
Huiyun Liang,Walter F. Ward,Youngmok C. Jang,Arunabh Bhattacharya,Arunabh Bhattacharya,Alex Bokov,Yan Li,Amanda L. Jernigan,Arlan Richardson,Arlan Richardson,Holly Van Remmen,Holly Van Remmen +11 more
TL;DR: A sustained level of excitatory amino acid transporter protein 2 (EAAT2) in astrocytes of the PGC‐1α/G93A DL mice may contribute to neuronal protection.
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Dietary restriction but not rapamycin extends disease onset and survival of the H46R/H48Q mouse model of ALS.
Arunabh Bhattacharya,Alex Bokov,Florian L. Muller,Amanda L. Jernigan,Keith Maslin,Vivian Diaz,Arlan Richardson,Holly Van Remmen +7 more
TL;DR: The findings suggest that the effect of DR in ALS is not mediated through pathways common with Rapa, the deleterious effect ofDR and Rapa in the G93A ALS mouse model may not be universal to disease caused by all SOD1 mutations, and the results reinforce the previous conclusions that the pathogenic mechanisms in G 93A and H46R/H48Q mice are distinct.
Journal ArticleDOI
Reduced mitochondrial ROS, enhanced antioxidant defense, and distinct age-related changes in oxidative damage in muscles of long-lived Peromyscus leucopus.
Yun Shi,Daniel Pulliam,Yuhong Liu,Ryan T. Hamilton,Amanda L. Jernigan,Arunabh Bhattacharya,Lauren B. Sloane,Wenbo Qi,Asish R. Chaudhuri,Rochelle Buffenstein,Zoltan Ungvari,Steven N. Austad,Holly Van Remmen +12 more
TL;DR: The results from young animals are in agreement with the predictions of the oxidative stress hypothesis of aging with the exception of protein carbonyls, which is more pronounced in short-lived M. musculus.
Journal ArticleDOI
Genetic ablation of 12/15-lipoxygenase but not 5-lipoxygenase protects against denervation-induced muscle atrophy
Arunabh Bhattacharya,Ryan T. Hamilton,Amanda L. Jernigan,Yiqiang Zhang,Marian Sabia,Md. Mizanur Rahman,Yan Li,Rochelle Wei,Asish R. Chaudhuri,Holly Van Remmen +9 more
TL;DR: A novel pathway for neurogenic muscle atrophy is revealed and it is suggested that 12/15-LO may be a potential therapeutic target in diseases associated with loss of innervation and Muscle atrophy.