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Yan Li
Researcher at Harbin Medical University
Publications - 52
Citations - 2365
Yan Li is an academic researcher from Harbin Medical University. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 17, co-authored 37 publications receiving 1665 citations. Previous affiliations of Yan Li include Veterans Health Administration & University of Texas Health Science Center at San Antonio.
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Journal ArticleDOI
Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.
Qianghu Wang,Baoli Hu,Xin Hu,Xin Hu,Hoon Kim,Massimo Squatrito,Lisa Scarpace,Ana C. deCarvalho,Sali Lyu,Pengping Li,Yan Li,Floris P. Barthel,Hee Jin Cho,Hee Jin Cho,Yu Hsi Lin,Nikunj Satani,Emmanuel Martinez-Ledesma,Siyuan Zheng,Edward I. Chang,Charles Etienne Gabriel Sauvé,Adriana Olar,Zheng D. Lan,Gaetano Finocchiaro,Joanna J. Phillips,Mitchel S. Berger,Konrad Gabrusiewicz,Guocan Wang,Eskil Eskilsson,Jian Hu,Tom Mikkelsen,Ronald A. DePinho,Florian L. Muller,Amy B. Heimberger,Erik P. Sulman,Do Hyun Nam,Do Hyun Nam,Roel G.W. Verhaak +36 more
TL;DR: Gene signature-based tumor microenvironment inference revealed a decrease in invading monocytes and a subtype-dependent increase in macrophages/microglia cells upon disease recurrence within weeks of diagnosis and at recurrence.
Journal ArticleDOI
Mice Deficient in Both Mn Superoxide Dismutase and Glutathione Peroxidase-1 Have Increased Oxidative Damage and a Greater Incidence of Pathology but No Reduction in Longevity
Yiqiang Zhang,Yuji Ikeno,Wenbo Qi,Asish R. Chaudhuri,Yan Li,Alex Bokov,Suzanne R. Thorpe,John W. Baynes,Charles J. Epstein,Arlan Richardson,Holly Van Remmen +10 more
TL;DR: Data do notsupport a significant role for increased oxidative stress as a result of compromised mitochondrial antioxidant defenses in modulating life span in mice and do not support the oxidative stress theory of aging.
Journal ArticleDOI
A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1-/- mice is correlated to increased cellular senescence.
Yiqiang Zhang,Archana Unnikrishnan,Sathyaseelan S. Deepa,Yuhong Liu,Yan Li,Yuji Ikeno,Danuta Sosnowska,Holly Van Remmen,Arlan Richardson,Arlan Richardson +9 more
TL;DR: It is proposed that various bouts of increased oxidative stress over the lifespan of an animal leads to the accumulation of senescent cells, which leads to increased inflammation, which plays a major role in the loss of function and increased pathology that are hallmark features of aging.
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Thioredoxin 2 haploinsufficiency in mice results in impaired mitochondrial function and increased oxidative stress.
Viviana I. Pérez,Christie M. Lew,Lisa A. Cortez,Celeste R. Webb,Marisela Rodriguez,Yuhong Liu,Wenbo Qi,Yan Li,Asish R. Chaudhuri,Holly Van Remmen,Arlan Richardson,Yuji Ikeno +11 more
TL;DR: The results suggest that Txn2 plays an important role in protecting the mitochondria against oxidative stress and in sensitizing the cells to ROS-induced apoptosis.
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Dietary restriction attenuates age-associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD
Young C. Jang,Young C. Jang,Yuhong Liu,Christopher R. Hayworth,Arunabh Bhattacharya,Michael S. Lustgarten,Florian L. Muller,Asish R. Chaudhuri,Asish R. Chaudhuri,Wenbo Qi,Wenbo Qi,Yan Li,Yan Li,Jing Yi Huang,Eric Verdin,Arlan Richardson,Arlan Richardson,Holly Van Remmen,Holly Van Remmen +18 more
TL;DR: Dietary restriction is a powerful mediator of mitochondrial function, mitochondrial ROS production, and oxidative damage, providing a solid protection against oxidative stress–induced neuromuscular defects and muscle atrophy in vivo even under conditions of high oxidative stress.