H
Hyang Woo Lee
Researcher at Sungkyunkwan University
Publications - 54
Citations - 1417
Hyang Woo Lee is an academic researcher from Sungkyunkwan University. The author has contributed to research in topics: Nitric oxide synthase & Nitric oxide. The author has an hindex of 19, co-authored 54 publications receiving 1360 citations. Previous affiliations of Hyang Woo Lee include Food and Drug Administration & Korea Research Institute of Bioscience and Biotechnology.
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Journal ArticleDOI
Apicidin, a Histone Deacetylase Inhibitor, Induces Apoptosis and Fas/Fas Ligand Expression in Human Acute Promyelocytic Leukemia Cells
So Hee Kwon,Seong Hoon Ahn,Yong Kee Kim,Gyu-Un Bae,Jong Woo Yoon,Sungyoul Hong,Hoi Young Lee,Yin Won Lee,Hyang Woo Lee,Jeung Whan Han +9 more
TL;DR: The results suggest that apicidin might induce apoptosis through selective induction of Fas/Fas ligand, resulting in the release of cytochrome c from the mitochondria to the cytosol and subsequent activation of caspase-9 and caspases-3.
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Expression of autotaxin (NPP-2) is closely linked to invasiveness of breast cancer cells.
So Young Yang,Jangsoon Lee,Chang Gyo Park,Seong Hwan Kim,Sungyoul Hong,Hyun Cheol Chung,Seong Ki Min,Jeung Whan Han,Hyang Woo Lee,Hoi Young Lee +9 more
TL;DR: The expression of ATX mRNA was found to be closely linked to invasiveness of cancer cells, and ATX-transfected MCF7 cells showed increased motility andInvasiveness than vector-transferred MCF 7 cells.
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S-adenosylmethionine: protein-arginine methyltransferase. Purification and mechanism of the enzyme.
TL;DR: The results suggest that the mechanism of the protein methylase I reaction is a Sequential Ordered Bi Bi mechanism with S-adenosyl-L-methionine as the first substrate, histone H4 as the second substrate, methylated hist one H4As the first product, and S- adenosyl -L-homocysteine asThe second product released.
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Suppression of inducible nitric oxide synthase expression in RAW 264.7 macrophages by two β-carboline alkaloids extracted from Melia azedarach
Byeong Gon Lee,Seung Hee Kim,Ok Pyo Zee,Kang Ro Lee,Hoi Young Lee,Jeung Whan Han,Hyang Woo Lee +6 more
TL;DR: The results suggest that suppression of iNOS and cyclooxygenase-2 induction by lipopolysaccharide is responsible for the anti-inflammatory activity of these alkaloids through selective inhibition of the expression of genes, which play important roles in inflammatory signaling pathways.
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Ergolide, sesquiterpene lactone from Inula britannica, inhibits inducible nitric oxide synthase and cyclo‐oxygenase‐2 expression in RAW 264.7 macrophages through the inactivation of NF‐κB
Jeung Whan Han,Byeong Gon Lee,Yong Kee Kim,Jong Woo Yoon,Hye Kyoung Jin,Sungyoul Hong,Hoi Young Lee,Kang Ro Lee,Hyang Woo Lee +8 more
TL;DR: The results demonstrate that the suppression of NF‐κB activation by ergolide might be attributed to the inhibition of nuclear translocation of NF'κB resulted from blockade of the degradation of IκB and the direct modification of active NF'KB, leading to the suppressed of the expression of iNOS and COX‐2, which play important roles in inflammatory signalling pathway.