Hylemariam Mihiretie Mengist

TL;DR: In this article, the structural basis of potential inhibitors targeting SARS-CoV-2 Mpro, identifies gaps, and provides future directions, highlighting compounds with potential Mpro based antiviral activity.

TL;DR: In this article, features of the cervicovaginal microbiota are found to be associated with the incidence of HPV-related diseases, presenting a novel approach to identify high-risk women through both blood and cervical samples.

TL;DR: The authors reported the X-ray structure of unliganded SARS-CoV-2 M and its complex with α-ketoamide inhibitor after a modification from the previously designed inhibitor through incorporating P3-P2 amide bond into pyridone ring so as to increase its half-life in plasma and demonstrated that the crystal structure of M provides a basis for designing of a potent inhibitor to the protease with a marked tropism to the lung and with ease of administration through

TL;DR: The antibody positivity rate increased corresponding with DPSO, but there was some decrement when moving from acute phase to convalescent phase of infection, and there was insufficient evidence to recommend CLIA/ELISA for clinical decision‐making, but likely to have comparative advantage over RT‐qPCR in certain circumstances and geographic regions.

TL;DR: The prevalence of intestinal helminthic infection and anemia among pregnant women attending ANC in East Wollega Zone, Ethiopia was significantly high and different socio-demographic, lifestyle and obstetric factors were identified as significant contributors.