T
Tengchuan Jin
Researcher at University of Science and Technology of China
Publications - 167
Citations - 7614
Tengchuan Jin is an academic researcher from University of Science and Technology of China. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 29, co-authored 125 publications receiving 5054 citations. Previous affiliations of Tengchuan Jin include Center for Excellence in Education & Chinese Academy of Sciences.
Papers
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Journal ArticleDOI
IFI16 is an innate immune sensor for intracellular DNA.
Leonie Unterholzner,Sinead E. Keating,Marcin Baran,Kristy A. Horan,Søren B. Jensen,Søren B. Jensen,Shrutie Sharma,Cherilyn M. Sirois,Tengchuan Jin,Eicke Latz,Eicke Latz,T. Sam Xiao,Katherine A. Fitzgerald,Søren R. Paludan,Andrew G. Bowie +14 more
TL;DR: IFI16 (p204) is the first PYHIN protein to their knowledge shown to be involved in IFN-β induction and forms a new family of innate DNA sensors the authors call 'AIM2-like receptors' (ALRs).
Journal ArticleDOI
Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor.
Tengchuan Jin,Andrew J. Perry,Jiansheng Jiang,Patrick F. Smith,James A. Curry,Leonie Unterholzner,Zhaozhao Jiang,Gabor Horvath,Vijay A. K. Rathinam,Ricky W. Johnstone,Ricky W. Johnstone,Veit Hornung,Eicke Latz,Eicke Latz,Andrew G. Bowie,Katherine A. Fitzgerald,T. Sam Xiao +16 more
TL;DR: These findings provide mechanistic insights into dsDNA as the activation trigger and oligomerization platform for the assembly of large innate signaling complexes such as the inflammasomes.
Journal ArticleDOI
Identification of a Selective and Direct NLRP3 Inhibitor to Treat Inflammatory Disorders
Hua Jiang,Hongbin He,Yun Chen,Wei Huang,J.-G. Cheng,Jin Ye,Aoli Wang,Aoli Wang,Jinhui Tao,Chao Wang,Qingsong Liu,Qingsong Liu,Tengchuan Jin,Wei Jiang,Xianming Deng,Rongbin Zhou +15 more
TL;DR: Treatment with CY-09 shows remarkable therapeutic effects on mouse models of cryopyrin-associated autoinflammatory syndrome (CAPS) and type 2 diabetes and indicates that NLRP3 can be targeted in vivo to combatNLRP3-driven diseases.
Journal ArticleDOI
Pharmacological Inhibitors of the NLRP3 Inflammasome.
TL;DR: This paper will review the various pharmacological inhibitors of the NLRP3 inflammasome and will also discuss their mechanism of action.
Journal ArticleDOI
Biochemical characterization of SARS-CoV-2 nucleocapsid protein.
Weihong Zeng,Guangfeng Liu,Huan Ma,Dan Zhao,Yunru Yang,Muziying Liu,Ahmed Mohammed,Changcheng Zhao,Yun Yang,Jiajia Xie,Chengchao Ding,Xiaoling Ma,Jianping Weng,Yong Gao,Hongliang He,Tengchuan Jin,Tengchuan Jin +16 more
TL;DR: Immunoblot assays confirmed the presence of IgA, IgM and IgG antibodies against N antigen in COVID-19 infection patients' sera, proving the importance of this antigen in host immunity and diagnostics.