Hyun S. Shin

TL;DR: Activation of the NF-kappa B/I- kappa B system in macrophages by ECM fragments may be an important mechanism for propagating the tissue inflammatory response.

TL;DR: These experiments support the hypothesis that certain biological effects induced by endotoxins may be mediated via the C' system, and may account for some of the known similarity in the reactivities evoked by endotoxic lipopolysaccharide, zymosan, or preformed immune complexes in vivo.

TL;DR: The fifth component of guinea pig complement, with a sedimentation coefficient 7.8S, is cleaved by sensitized sheep erythrocytes treated with the first four components of complement into two fragments with sedimentation coefficients of 7.4S and 1.5S, which possesses chemotactic activity for rabbit polymorphonuclear leukocytes, as well as anaphylatoxic activity for Guinea pig ileum.

TL;DR: Evidence is presented that the early phase of alpha-thrombin-stimulated 1,2-diacylglycerol production is related to R1, which is characterized by: 1) increased release of arachidonic acid, 2) hydrolysis of polyphosphoinositides, and 3) inhibition by pretreating cultures with chymotrypsin.

TL;DR: It is concluded that the majority of chemotactic activity found in whole guinea pig serum after interaction with endotoxin is a product cleaved from C′5.