Hyun Soo Yoon

TL;DR: It is shown that some of the ES-specific miRNA genes are highly related to each other, organized as clusters, and transcribed as polycistronic primary transcripts, suggesting that they may operate key regulatory networks conserved in mammalian pluripotent stem cells.

TL;DR: Patient-specific, immune-matched human embryonic stem cells (hESCs) are anticipated to be of great biomedical importance for studies of disease and development and to advance clinical deliberations regarding stem cell transplantation, but before clinical use of these cells can occur, preclinical evidence is required to prove that transplantation of differentiated NT-hESC can be safe, effective, and tolerated.

TL;DR: Patient-specific, immune-matched human embryonic stem cells (hESCs) are anticipated to be of great biomedical importance for studies of disease and development and to advance clinical deliberations regarding stem cell transplantation, but before clinical use of these cells can occur, preclinical evidence is required to prove that transplantation of differentiated NT-hESC can be safe, effective, and tolerated.

TL;DR: Results suggest that differentiation of hESCs into cardiomyocytes can be enhanced by the combination of hanging drop culture and 5-azacytidine treatment, and the methylation status of genes related to cardiomeocyte development may play an important role in the differentiation.

TL;DR: This study attempted to establish new hES cell lines using human uterine endometrial cells (hUECs) to prevent the risks associated with animal feeder cells and for their eventual application in cell-replacement therapy.