I
I. L. Gubskiy
Researcher at Russian National Research Medical University
Publications - 33
Citations - 324
I. L. Gubskiy is an academic researcher from Russian National Research Medical University. The author has contributed to research in topics: Medicine & Transplantation. The author has an hindex of 6, co-authored 22 publications receiving 185 citations.
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Journal ArticleDOI
Luciferase Expression Allows Bioluminescence Imaging But Imposes Limitations on the Orthotopic Mouse (4T1) Model of Breast Cancer
Vladimir P. Baklaushev,Vladimir P. Baklaushev,Athina Kilpelainen,Athina Kilpelainen,Stefan Petkov,Maxim A. Abakumov,N. F. Grinenko,G. M. Yusubalieva,A. A. Latanova,I. L. Gubskiy,F G Zabozlaev,Elizaveta Starodubova,Tatiana O. Abakumova,Maria G. Isaguliants,Vladimir P. Chekhonin +14 more
TL;DR: Data show that natural or induced cellular response against the reporter restricts growth and metastatic activity of the reporter-labelled tumor cells, which represent a powerful instrument for improving immunization technique for cancer vaccine applications.
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Treatment of glioma by cisplatin-loaded nanogels conjugated with monoclonal antibodies against Cx43 and BSAT1.
Vladimir P. Baklaushev,N. V. Nukolova,Alexander S. Khalansky,Olga I. Gurina,G. M. Yusubalieva,Nadejhda Ph Grinenko,I. L. Gubskiy,P. A. Mel’nikov,Karina Sh Kardashova,Alexander V. Kabanov,Vladimir P. Chekhonin +10 more
TL;DR: The efficiency of mAb-targeted cisplatin-loaded nanogels conjugated with monoclonal antibodies to Cx43 and BSAT1 in the experimental model of glioma 101/8 is demonstrated for the first time and could facilitate the development of new drug delivery systems for the treatment ofgliomas.
Journal ArticleDOI
MRI Guiding of the Middle Cerebral Artery Occlusion in Rats Aimed to Improve Stroke Modeling
I. L. Gubskiy,D. D. Namestnikova,E A Cherkashova,Vladimir P. Chekhonin,Vladimir P. Baklaushev,Leonid V. Gubsky,Konstantin N. Yarygin +6 more
TL;DR: MRI-guided middle cerebral artery occlusion technique permits intra-operational monitoring via direct non-invasive simultaneous visualization of the filament, blood flow in the arteries, brain tissue, and hemorrhagic complications and provides better assessment of MCAO outcomes in individual animals and significant enhancement of M CAO success rate.
Journal ArticleDOI
Multilayer polyion complex nanoformulations of superoxide dismutase 1 for acute spinal cord injury.
N. V. Nukolova,A.D. Aleksashkin,Tatiana O. Abakumova,Anna Morozova,I. L. Gubskiy,Е.А. Kirzhanova,Maxim A. Abakumov,Vladimir P. Chekhonin,Natalia L. Klyachko,Alexander V. Kabanov,Alexander V. Kabanov +10 more
TL;DR: The SOD1 DC nanozymes are promising modality for scavenging ROS, decreasing inflammation and edema, and improving recovery after SCI, based on the testing in a rodent model.
Journal ArticleDOI
Methodological aspects of MRI of transplanted superparamagnetic iron oxide-labeled mesenchymal stem cells in live rat brain.
D. D. Namestnikova,I. L. Gubskiy,I. V. Kholodenko,P. A. Mel’nikov,K. K. Sukhinich,A. N. Gabashvili,Daniil A. Vishnevskiy,Anastasia Soloveva,Maxim A. Abakumov,Maxim A. Abakumov,I. V. Vakhrushev,Alexei Y Lupatov,Vladimir P. Chekhonin,Leonid V. Gubsky,Konstantin N. Yarygin +14 more
TL;DR: This study confirms the possibility of single cell tracing in live brain and outlines the necessary conditions, and shows that SWI (Susceptibility-Weighted Imaging) presents the most sensitive pulse sequence for SPIO-labeled MSCs MR visualization.