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I.M. Clark
Publications - 2
Citations - 273
I.M. Clark is an academic researcher. The author has contributed to research in topics: Cyclic nucleotide-binding domain & Crystal structure. The author has an hindex of 2, co-authored 2 publications receiving 268 citations.
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Structure of full-length porcine synovial collagenase reveals a C-terminal domain containing a calcium-linked, four-bladed β-propeller
J. Li,Peter Brick,M.C. Ohare,Tadeusz Skarzynski,Lesley F. Lloyd,VA Curry,I.M. Clark,HF Bigg,BL Hazleman,T.E. Cawston,David M. Blow +10 more
TL;DR: The C-terminal domain of collagenases MMP-1 provides a structural model for haemopexin and its homologues, and controls the specificity of MMPs, affecting both substrate and inhibitor binding, although its role remains obscure.
Journal ArticleDOI
Crystallization and preliminary X-ray analysis of porcine synovial collagenase.
Lesley F. Lloyd,Tadeusz Skarżyński,A.J. Wonacott,T.E. Cawston,I.M. Clark,C.J. Mannix,G.P. Harper +6 more
TL;DR: Crystals of porcine synovial collagenase suitable for an X-ray structure analysis have been obtained and diffraction extends beyond 3 A perpendicular to the c axis but along the 4-fold axis, the intensities are measurable only to 4 A.