I. Saenz de Tejada

TL;DR: It is concluded that endothelium-mediated responses of corpus cavernosum smooth muscle are mediated by a diffusible nitric oxide-like substance, and NANC neurogenic inhibitory responses do not require functional endot Helium, and nitricoxide, or a closely related substance, may act as an inhibitory neurotransmitter in penile corpus cavernsum smooth Muscle.

TL;DR: Investigation of the physiological role of oxygen tension in the regulation of trabecular smooth muscle tone concluded that physiological concentrations of oxygen modulate penile erection by regulating nitric oxide synthesis in corpus cavernosum tissue.

TL;DR: The selectivity for PDE5, the potentiation of NO-induced relaxation and cGMP accumulation in human trabecular smooth muscle and the ability to enhance No-induced erection in vivo indicate that vardenafil has the appropriate properties to be a potential compound for the treatment of erectile dysfunction.

TL;DR: Investigating the role of cholinergic neurotransmission in erection found endothelium lining the lacunar spaces within human corpus cavernosum is required for the relaxation caused by exogenous acetylcholine.

TL;DR: It is concluded that human corpus cavernosum endothelium has the ability to synthesize and release endothelin, that endothelins contract corporeal smooth muscle, and that at least two distinctendothelin receptors may exist and are differentiated by their affinity for ET-3.