Showing papers by "Iain R. Gibson published in 2010"
TL;DR: The osteocompatibility of the chitosan hybrid membranes in the chITosan–GPTMS–TEOS system can be controlled by the amount of Si(IV) released from them when they are applied to cell culture.
Abstract: Chitosan–γ-glycidoxypropyltrimethoxysilane (GPTMS)–tetraethoxysilane (TEOS) hybrid membranes were prepared by the sol–gel method. The effects of Si(IV) released from them on cell proliferation and differentiation were examined in terms of cell metabolic activity and the alkaline phosphatase (ALP) activity of MG63 osteoblastic cells. The amount of Si(IV) released from the hybrid membranes increased with the TEOS content. The released Si(IV) inhibited cell proliferation but promoted cell differentiation. Thus, the osteocompatibility of the chitosan hybrid membranes in the chitosan–GPTMS–TEOS system can be controlled by the amount of Si(IV) released from them when they are applied to cell culture.
20 citations
TL;DR: Osteocompatibility of the chitosan hybrid membranes can be controlled due to the amount of Si(IV) released from them as the hybrids in the system chitOSan-GPTMS-TEOS are applied for cell culture.
Abstract: Chitosan-?-glycidoxypropyltrimethoxysilane (GPTMS)-tetraethoxysilane (TEOS) hybrid membranes were prepared by a sol-gel method. Effects of Si(IV) released from them on proliferation and differentiation were examined in terms of cell metabolic activity and alkaline phosphatase (ALP) activity of MG63 osteoblastic cells. The amount of Si(IV) released from the hybrid membranes increased with the TEOS content. Released Si(IV) inhibited cell proliferation, while it promoted cell differentiation. Thus, osteocompatibility of the chitosan hybrid membranes can be controlled due to the amount of Si(IV) released from them as the hybrids in the system chitosan-GPTMS-TEOS are applied for cell culture.
7 citations