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Ian H. Parkinson
Researcher at University of Adelaide
Publications - 67
Citations - 2763
Ian H. Parkinson is an academic researcher from University of Adelaide. The author has contributed to research in topics: Cancellous bone & Bone remodeling. The author has an hindex of 26, co-authored 67 publications receiving 2624 citations. Previous affiliations of Ian H. Parkinson include South Australia Pathology.
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Journal ArticleDOI
Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis
Susan Branford,Zbigniew Rudzki,Sonya Walsh,Ian H. Parkinson,Andrew Grigg,Jeff Szer,Kerry Taylor,Richard Herrmann,John F. Seymour,Christopher Arthur,David Joske,Kevin R. Lynch,Timothy P. Hughes +12 more
TL;DR: The detection of kinase domain mutations using a direct sequencing technique was almost always associated with imatinib resistance, and patients with mutations in the P-loop had a particularly poor prognosis.
Journal ArticleDOI
Real-time quantitative PCR analysis can be used as a primary screen to identify patients with CML treated with imatinib who have BCR-ABL kinase domain mutations.
Susan Branford,Zbigniew Rudzki,Ian H. Parkinson,Andrew Grigg,Kerry Taylor,John F. Seymour,Simon Durrant,Peter Browett,Anthony P. Schwarer,Christopher Arthur,John G. Catalano,Michael F. Leahy,Robin Filshie,Kenneth F. Bradstock,Richard Herrmann,David Joske,Kevin R. Lynch,Timothy P. Hughes +17 more
TL;DR: It is concluded that a rise in BCR-ABL of more than 2-fold can be used as a primary indicator to test patients for BCR -ABL kinase domain mutations.
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Fractal dimension and architecture of trabecular bone.
TL;DR: The fractal dimension of trabecular bone was determined for biopsies from the proximal femur of 25 subjects undergoing hip arthroplasty and provides a measure which does not rely on Euclidean descriptors in order to describe a complex geometry.
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Intervertebral disc disorganization is related to trabecular bone architecture in the lumbar spine.
TL;DR: It appears that trabecular morphology is related to the condition of the associated IVD, rather than being the sole consequence of a loss of BV/TV with age, which could influence the occurrence of vertebral body crush fracture.
Journal ArticleDOI
Mechanical and pathologic consequences of induced concentric anular tears in an ovine model.
Nicola L. Fazzalari,John J. Costi,Trevor C. Hearn,Robert D. Fraser,Barrie Vernon-Roberts,John Hutchinson,Beverley A. Manthey,Ian H. Parkinson,Case Sinclair +8 more
TL;DR: In the isolated disc, the disc stiffness at 6 months was increased for right bending, as compared with the response at 1 month, which was associated with increased anterior lamellar thickening and increased vertebral body bone volume fraction.