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Kerry Taylor

Researcher at Australian National University

Publications -  200
Citations -  16213

Kerry Taylor is an academic researcher from Australian National University. The author has contributed to research in topics: Ontology (information science) & Wireless sensor network. The author has an hindex of 42, co-authored 195 publications receiving 15143 citations. Previous affiliations of Kerry Taylor include University of Surrey & City University of New York.

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Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia

TL;DR: After 5 years of follow-up, continuous treatment of chronic-phase CML with imatinib as initial therapy was found to induce durable responses in a high proportion of patients.
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Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis

TL;DR: The detection of kinase domain mutations using a direct sequencing technique was almost always associated with imatinib resistance, and patients with mutations in the P-loop had a particularly poor prognosis.
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High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance.

TL;DR: A high frequency of mutations clustered within the ATP-binding region of BCR/ABL in resistant patients is confirmed and may allow intervention before relapse by identifying emerging mutations with defined impacts on imatinib binding.