Ian Woolhouse

TL;DR: This guideline is based on a comprehensive review of the literature on pulmonary nodules and expert opinion and provides more clarity in the use of further imaging and more clarity about the place of biopsy.

TL;DR: The results suggest that the bronchial secretions of COPD patients with α1–AT deficiency have increased neutrophil chemotactic activity, and this relates to the increased levels of IL-8 and, in particular LTB4, which accounted most of the sputum chemistry activity in the patients with COPD as a whole.

TL;DR: Sputum processing with DTT significantly reduces the detectable concentration of TNFα, LTB4 and MPO, and produces a small but significant increase in median α1-AT levels, recommending that an untreated aliquot of sputum be retained for cytokine analysis.

TL;DR: Data collected for the UK National Lung Cancer Audit is used to assess current practice and to highlight regional variation in the management of mesothelioma patients, as well as to describe survival patterns in subgroups.

TL;DR: The enhanced endothelial interaction of neutrophils from smokers who have developed chronic obstructive pulmonary disease in the presence of normal levels of α1-antitrypsin deficiency, but not in those with severe α 1-antitsin deficiency is suggests that this is a predisposing factor for the development of the disease, and upregulation of macrophage antigen-1 may be responsible.