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Ibrahim Zgani
Researcher at Virginia Commonwealth University
Publications - 4
Citations - 62
Ibrahim Zgani is an academic researcher from Virginia Commonwealth University. The author has contributed to research in topics: Aquation & Zinc finger. The author has an hindex of 4, co-authored 4 publications receiving 58 citations.
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Chimeric platinum-polyamines and DNA binding. Kinetics of DNA interstrand cross-link formation by dinuclear platinum complexes with polyamine linkers.
Rasha A. Ruhayel,Janina S. Langner,Janina S. Langner,Matilda-Jane Oke,Susan J. Berners-Price,Ibrahim Zgani,Nicholas Farrell +6 more
TL;DR: The first observation of a polyamine-DNA interaction using 2D HSQC NMR spectroscopy allows study of the role of the linker in polynuclear platinum-DNA interactions and a novel "anchoring" of the polyamine by Pt-DNA bond formation allows examination of the details of conformational B → Z transitions induced by the polyamines.
Journal ArticleDOI
Receptor for anionic pyrene derivatives provides the basis for new biomembrane assays.
TL;DR: The most important finding was the ability of cyclen 1 to bind efficiently to a pH-sensitive dye pyranine, a dye that is commonly used in various biomembrane assays and finds limited applicability to the detection of endovesiculation.
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Solution studies of dinuclear polyamine-linked platinum-based antitumour complexes
Rasha A. Ruhayel,Ibrahim Zgani,Susan J. Berners-Price,Susan J. Berners-Price,Nicholas Farrell,Nicholas Farrell +5 more
TL;DR: The aquation profiles of two novel dinuclear polyamine-linked, platinum-based antitumour complexes and the rate constants for the hydrolysis of 1 and 1', as well as the acid dissociation constants of the coordinated aqua ligands in their aquated derivatives are reported.
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Zinc finger peptide cleavage by a dinuclear platinum compound.
TL;DR: Electrospray ionisation mass spectrometry (ESI-MS) and NMR spectroscopy has elucidated the binding of a dinuclear platinum compound to a zinc finger peptide with induced backbone cleavage.