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Ichiro Nakashima
Researcher at Tohoku Pharmaceutical University
Publications - 320
Citations - 15489
Ichiro Nakashima is an academic researcher from Tohoku Pharmaceutical University. The author has contributed to research in topics: Neuromyelitis optica & Multiple sclerosis. The author has an hindex of 54, co-authored 292 publications receiving 12626 citations. Previous affiliations of Ichiro Nakashima include Montreal Neurological Institute and Hospital & Nitte University.
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Journal ArticleDOI
A serum autoantibody marker of neuromyelitis optica : distinction from multiple sclerosis
Vanda A. Lennon,Dean M. Wingerchuk,Thomas J. Kryzer,Sean J. Pittock,C. F. Lucchinetti,Kazuo Fujihara,Ichiro Nakashima,Brian G. Weinshenker +7 more
TL;DR: NMO-IgG is a specific marker autoantibody of neuromyelitis optica and binds at or near the blood-brain barrier that distinguishes neuromyleitis opticas from multiple sclerosis.
Journal ArticleDOI
Distinction between MOG antibody-positive and AQP4 antibody-positive NMO spectrum disorders
Douglas Kazutoshi Sato,Dagoberto Callegaro,Marco Aurélio Lana-Peixoto,Patrick Waters,Frederico Jorge,Toshiyuki Takahashi,Ichiro Nakashima,Samira Luisa Apostolos-Pereira,Natalia Talim,Renata Simm,Angelina Maria Martins Lino,Tatsuro Misu,Maria Isabel Leite,Masashi Aoki,Kazuo Fujihara +14 more
TL;DR: Patients with NMOSD with MOG antibodies have distinct clinical features, fewer attacks, and better recovery than patients with AQP4 antibodies or patients seronegative for both antibodies.
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Loss of aquaporin 4 in lesions of neuromyelitis optica: distinction from multiple sclerosis.
Tatsuro Misu,Kazuo Fujihara,Akiyoshi Kakita,H. Konno,M. Nakamura,S. Watanabe,Tetsuya Takahashi,Ichiro Nakashima,Hitoshi Takahashi,Yasuto Itoyama +9 more
TL;DR: It is demonstrated that the immunoreactivities of AQP4 and GFAP were consistently lost from the early stage of the lesions in NMO, notably in the perivascular regions with complement and immunoglobulin deposition.
Journal ArticleDOI
Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO: a study on antibody titre.
Toshiyuki Takahashi,Kazuo Fujihara,Ichiro Nakashima,Tatsuro Misu,Isabelle Miyazawa,Masashi Nakamura,Shohei Watanabe,Yusei Shiga,Chihiro Kanaoka,Juichi Fujimori,Shigeru Sato,Yasuto Itoyama +11 more
TL;DR: In this article, the authors established a sensitive anti-AQP4 antibody assay using human AQP4-transfected cells, which appeared more sensitive than the original NMO-IgG assay.
Journal Article
Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO : a study on antibody titre. Commentary
Alastair Compston,Toshiyuki Takahashi,Kazuo Fujihara,Ichiro Nakashima,Tatsuro Misu,Isabelle Miyazawa,Masashi Nakamura,Shohei Watanabe,Yusei Shiga,Chihiro Kanaoka,Juichi Fujimori,Shigeru Sato,Yasuto Itoyama +12 more
TL;DR: Using a sensitive assay, the results of the present study suggest that NMO and high-risk syndrome may be essentially anti-AQP4 antibody-associated disorders, and that the anti- AQP 4 antibody titres have significant clinical and immunological implications in NMO.