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Sean J. Pittock
Researcher at Mayo Clinic
Publications - 436
Citations - 34734
Sean J. Pittock is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Neuromyelitis optica & Medicine. The author has an hindex of 77, co-authored 351 publications receiving 27755 citations. Previous affiliations of Sean J. Pittock include University of Rochester & Royal College of Surgeons in Ireland.
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Journal ArticleDOI
A serum autoantibody marker of neuromyelitis optica : distinction from multiple sclerosis
Vanda A. Lennon,Dean M. Wingerchuk,Thomas J. Kryzer,Sean J. Pittock,C. F. Lucchinetti,Kazuo Fujihara,Ichiro Nakashima,Brian G. Weinshenker +7 more
TL;DR: NMO-IgG is a specific marker autoantibody of neuromyelitis optica and binds at or near the blood-brain barrier that distinguishes neuromyleitis opticas from multiple sclerosis.
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Revised diagnostic criteria for neuromyelitis optica
TL;DR: Revised diagnostic criteria for definite neuromyelitis optica (NMO) that require optic neuritis, myelitis, and at least two of three supportive criteria: MRI evidence of a contiguous spinal cord lesion 3 or more segments in length, onset brain MRI nondiagnostic for multiple sclerosis, or NMO-IgG seropositivity.
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IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel.
TL;DR: It is shown that NMO-IgG binds selectively to the aquaporin-4 water channel, a component of the dystroglycan protein complex located in astrocytic foot processes at the blood-brain barrier, which may represent the first example of a novel class of autoimmune channelopathy.
Journal ArticleDOI
The spectrum of neuromyelitis optica
Dean M. Wingerchuk,Vanda A. Lennon,Claudia F. Lucchinetti,Sean J. Pittock,Brian G. Weinshenker +4 more
TL;DR: Data suggest that autoantibodies to aquaporin 4 derived from peripheral B cells cause the activation of complement, inflammatory demyelination, and necrosis that is seen in neuromyelitis optica.
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Brain abnormalities in neuromyelitis optica.
Sean J. Pittock,Vanda A. Lennon,Karl N. Krecke,Dean M. Wingerchuk,Claudia F. Lucchinetti,Brian G. Weinshenker +5 more
TL;DR: MRI brain findings in NMO justify revision of diagnostic criteria for NMO to allow for brain involvement, and asymptomatic brain lesions do not exclude the diagnosis of NMO.