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Ikram M. Said
Researcher at National University of Malaysia
Publications - 40
Citations - 686
Ikram M. Said is an academic researcher from National University of Malaysia. The author has contributed to research in topics: Mitragyna speciosa & Indole alkaloid. The author has an hindex of 15, co-authored 40 publications receiving 629 citations. Previous affiliations of Ikram M. Said include Chiba University.
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In vitro antiamoebic and antiplasmodial activities of alkaloids isolated from Alstonia angustifolia roots
Colin W. Wright,David J. Allen,Ya Cai,J. D. Phillipson,Ikram M. Said,G. C. Kirby,D. C. Warhurst +6 more
TL;DR: Three dimeric alkaloids, macrocarpamine, macralstonine acetate (semisynthetic) and villastonine were found to possess significant activity against both protozoans, but were 4–8 times less potent than emetine against E. histolytica and 15–50 times more potent than chloroquine against P. falciparum.
Journal Article
Genes induced by high concentration of salicylic acid in Mitragyna speciosa
TL;DR: Most genes responding to acute SA treatment are related to stress and signaling pathways which eventually led to cell death, including genes encoding chaperone, heatshock proteins (HSPs), antioxidants and genes involved in secondary metabolite biosynthesis.
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Cytotoxic properties of oligostilbenoids from the tree barks of Hopea dryobalanoides.
Sahidin,Euis H. Hakim,Lia D. Juliawaty,Yana M. Syah,Laily B. Din,Emilio L. Ghisalberti,Jalifah Latip,Ikram M. Said,Sjamsul Arifin Achmad +8 more
TL;DR: A new modified stilbene dimer, diptoindonesin D, was isolated from the acetone extract of the tree bark of Hopea dryobalanoides and found to be the most active with IC50 of 5.7 μm.
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A new indole alkaloid, 7-hydroxyspeciociliatine, from the fruits of Malaysian Mitragyna speciosa and its opioid agonistic activity
Mariko Kitajima,Kaori Misawa,Noriyuki Kogure,Ikram M. Said,Syunji Horie,Yoshio Hatori,Toshihiko Murayama,Hiromitsu Takayama +7 more
TL;DR: The new indole alkaloid isolated from the fruits of Malaysian Mitragyna speciosa Korth was found to have a weak stimulatory effect on μ-opioid receptors and was investigated in guinea-pig ileum experiments.
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New indole alkaloids from the leaves of Malaysian Mitragyna speciosa
TL;DR: Three new monoterpenoid indole alkaloids, i.e., 3,4,5,6-tetradehydromitragynine, mitralactonal, and mitrasulgynine carrying a sulfonate function, were isolated, together with seven known compounds, from the leaves of Mitragyna speciosa native to Malaysia as mentioned in this paper.