S
Syunji Horie
Researcher at Josai International University
Publications - 112
Citations - 3086
Syunji Horie is an academic researcher from Josai International University. The author has contributed to research in topics: TRPV1 & Gastric acid. The author has an hindex of 30, co-authored 107 publications receiving 2783 citations. Previous affiliations of Syunji Horie include Queen Mary University of London & Chulalongkorn University.
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Journal ArticleDOI
Antinociceptive effect of 7-hydroxymitragynine in mice: Discovery of an orally active opioid analgesic from the Thai medicinal herb Mitragyna speciosa.
Kenjiro Matsumoto,Syunji Horie,Hayato Ishikawa,Hiromitsu Takayama,Norio Aimi,Dhavadee Ponglux,Kazuo Watanabe +6 more
TL;DR: It was found that 7-hydroxymitragynine is a novel opioid agonist that is structurally different from the other opioid agonists, and has potent analgesic activity when orally administered.
Journal ArticleDOI
Immunohistochemical co-localization of transient receptor potential vanilloid (TRPV)1 and sensory neuropeptides in the guinea-pig respiratory system.
N Watanabe,Syunji Horie,Gregory J. Michael,Sandra Keir,Domenico Spina,Clive P. Page,John V. Priestley +6 more
TL;DR: Evidence is provided of heterogeneity of TRPV1 positive nerve fibers, including fibers characterized by lack of co-localization with neuropeptides in various regions of the airways and the existence of Neuropeptide containing fibers that were not TRPv1 positive in guinea-pigs.
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Inhibitory effect of mitragynine, an alkaloid with analgesic effect from Thai medicinal plant Mitragyna speciosa, on electrically stimulated contraction of isolated guinea-pig ileum through the opioid receptor
TL;DR: The present results suggest that mitragynine inhibits the electrically stimulated contraction of guinea-pig ileum through the opioid receptor.
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Contractile effect of TRPA1 receptor agonists in the isolated mouse intestine.
Angelica Penuelas,Kimihito Tashima,Shizuko Tsuchiya,Kenjiro Matsumoto,Tomonori Nakamura,Syunji Horie,Shingo Yano +6 more
TL;DR: TRPA1, but not TRPM8, are functionally expressed in the enteric nervous system throughout the mouse intestine on neurons that may also co-express TRPV1, yet the contractile responses to TRPA1 activation differ depending on their location along the intestine.
Journal ArticleDOI
Opioid receptor agonistic characteristics of mitragynine pseudoindoxyl in comparison with mitragynine derived from Thai medicinal plant Mitragyna speciosa.
Leonardo T. Yamamoto,Syunji Horie,Hiromitsu Takayama,Norio Aimi,Shin-ichiro Sakai,Shingo Yano,Jie Shan,Peter K.T. Pang,Dhavadee Ponglux,Kazuo Watanabe +9 more
TL;DR: It is demonstrated that mitragynine pseudoindoxyl, a novel alkaloid structurally different from other opioid agonists, acts on opioid receptors, leading to a potent inhibition of electrically stimulated contraction in the ileum through the micro-receptors and in mouse vas deferens through delta-receptionors.