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Showing papers by "Ilan S. Wittstein published in 2017"

Journal Article•DOI•
Myocardial Recovery in Patients With Systolic Heart Failure and Autoantibodies Against β1-Adrenergic Receptors

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Yuji Nagatomo1, Dennis M. McNamara2, Jeffrey D. Alexis3, Leslie T. Cooper4, G. William Dec5, Daniel F. Pauly6, Richard Sheppard7, Randall C. Starling1, W.H. Wilson Tang1, Karen Janosko, Charles F. McTiernan, Barry London, Karen Hanley-Yanez, John Gorcsan, Hidekazu Tanaka, Mathew Suffoletto, Cynthia Oblak, Annette McNallan, Lu Anne Koenig, Paul J. Mather, Natalie Pierson, Sharon Rubin, Yanique Bell, Alicia Ervin, John P. Boehmer8, Patricia Frey, Jeffrey D. Alexis9, Janice Schrack, Pam LaDuke, Guillermo Torre-Amione, Jeannie Arredondo, Pamela C. Smith, Stephanie Fuoco, Ilan S. Wittstein, Elayne Breton, Vinay Thohan, Deborah J. Wesley, Diane Cocca-Spofford, David W. Markham, Lynn Fernandez, Colleen H. Debes, Mark J. Zucker, Laura Adams, Peter Liu, Judith Renton, Jagat Narula, Byron Allen, Elizabeth Westberg •
Cleveland Clinic1, University of Pittsburgh2, University of Rochester3, Mayo Clinic4, Harvard University5, Truman Medical Center6, McGill University7, Pennsylvania State University8, University of Rochester Medical Center9
28 Feb 2017-Journal of the American College of Cardiology
TL;DR: In patients with high New York Heart Association functional class (III or IV) at baseline, the IgG3 group had a lower incidence of the composite endpoint of all-cause death, cardiac transplantation, and hospitalization due to heart failure, whereas the non-IgG3 groups had the highest incidence ofthe composite endpoint.

25 citations

Journal Article•DOI•
Baseline Characteristics Predict the Presence of Amyloid on Endomyocardial Biopsy.

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Van-Khue Ton1, Van-Khue Ton2, Aditya Bhonsale1, Nisha A. Gilotra1, Marc K. Halushka1, Charles Steenbergen1, Johana Almansa1, Emily Brown1, Ryan J. Tedford1, Ilan S. Wittstein1, Kavita Sharma1, Stuart D. Russell1, Daniel P. Judge1 •
Johns Hopkins University1, University of Maryland Medical Center2
01 Apr 2017-Journal of Cardiac Failure
TL;DR: Clinicians should be suspicious of CAm in patients with EF 50%-75%, >50 years of age, BMI <30 kg/m2, peripheral neuropathy, Sokolow-Lyon index ≤15 mm, and septal wall thickness ≥1.4 cm.

13 citations

Journal Article•DOI•
Usefulness of Pulse Amplitude Changes During the Valsalva Maneuver Measured Using Finger Photoplethysmography to Identify Elevated Pulmonary Capillary Wedge Pressure in Patients With Heart Failure.

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Nisha A. Gilotra1, Ryan J. Tedford1, Ilan S. Wittstein1, Gayane Yenokyan2, Kavita Sharma1, Stuart D. Russell1, Harry A. Silber1 •
Johns Hopkins University School of Medicine1, Johns Hopkins University2
15 Sep 2017-American Journal of Cardiology
TL;DR: It is demonstrated that noninvasively measured response to the Valsalva maneuver in patients with HF can estimate pulmonary capillary wedge pressure and also detect changes within a single patient.
Abstract: The pulse amplitude ratio, the ratio of pulse pressure at the end of a Valsalva maneuver to before the onset of Valsalva, correlates with filling pressure. This study aimed to noninvasively estimate cardiac filling pressure in patients with heart failure. We developed a noninvasive handheld device to measure pulse amplitude ratio using finger photoplethysmography. In 69 patients who underwent right heart catheterization, photoplethysmography waveforms were recorded during a standardized Valsalva maneuver, and in 60 of these patients, pulse amplitude ratio was able to be calculated. Pulse amplitude ratio correlated with pulmonary capillary wedge pressure (PCWP) (r = 0.58, p 15 mm Hg was statistically significant (p 15 mm Hg with 73% sensitivity and 77% specificity. Pulse amplitude ratio also increased by an average of 0.03 with a leg raise maneuver (p = 0.05, n = 36). In conclusion, we demonstrate that noninvasively measured response to the Valsalva maneuver in patients with HF can estimate PCWP and also detect changes within a single patient.

11 citations