Ilaria Varotto-Boccazzi

TL;DR: In this article, the complex interaction between the intestinal microbiota and mosquito females defenses, both in the gut and at humoral level, has been investigated for the development of novel and targeted strategies for the control of mosquitoborne diseases such as the use of paratransgenesis or taking advantage of the relationship between Wolbachia and mosquito hosts.

TL;DR: It is shown that Wolbachia surface protein (WSP) activates host innate immunity in mosquitoes, inhibiting the development of the heartworm parasite in its insect host.

TL;DR: The results of the present study confirm the immunostimulating properties of WSP highlighting a potential therapeutic efficacy against Leishmania parasites and Asaia was designed as a delivery system for WSP, thus developing a novel type of immunomodulating agent, worthy of being investigated for immuno-prophylaxis and -therapy of leishmaniases and other diseases that could be subverted by M1 macrophage activation.

TL;DR: The observed antagonistic effect of doxycycline in combination with ivermectin or elacridar highlighted the importance of drug testing, to avoid the de-facto generation of a sub-dosage, a condition that facilitates the development of drug resistance.

TL;DR: The most recent evidences on dysbiotic changes associated with gut inflammation, as well as environmental and genetic factors contributing to IBD pathogenesis are discussed, with a focus on the peculiarities of the pediatric age.