Marco Biggiogera

TL;DR: It is proved that the rescue of cellular homeostasis following 4-PBA treatment is associated with its chaperone activity, since it increases protein secretion, restoring ER proteostasis and reducing PERK activation and cell survival also in the presence of pharmacological inhibition of autophagy.

TL;DR: It is reported that CANT1 plays a crucial role in cartilage proteoglycan synthesis and in endochondral ossification and that the pathogenic mechanism of DBQD1 comprises deregulated chondrocyte performance due to defective intracellular proteogly can synthesis and altered proteogly Can properties in the extracellular matrix.

TL;DR: It is shown that Wolbachia surface protein (WSP) activates host innate immunity in mosquitoes, inhibiting the development of the heartworm parasite in its insect host.

TL;DR: This work visualized DNA methylation status and RNA methylation sites in the interphase nucleus of HeLa cells and rat hepatocytes by ultrastructural immunocytochemistry and cytochemical staining, which represents an efficient alternative to study nucleic acid methylation.

TL;DR: It is shown that SatIII RNAs and nSBs are detectable up to four days after thermal stress and are linked to defects in chromosome behavior during mitosis and may contribute to chromosomal instability.