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Ilary Allodi
Researcher at University of Copenhagen
Publications - 27
Citations - 987
Ilary Allodi is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Motor neuron & Amyotrophic lateral sclerosis. The author has an hindex of 12, co-authored 25 publications receiving 757 citations. Previous affiliations of Ilary Allodi include Karolinska Institutet & Autonomous University of Barcelona.
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Specificity of peripheral nerve regeneration: interactions at the axon level.
TL;DR: The aim of this review is to understand if some of these molecular factors implicated in axonal regeneration and pathfinding after injury are specific for motor and sensory neuron growth, and provide the basic knowledge for potential strategies to enhance and guide axonal regenerate and reinnervation of adequate target organs.
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Effects of activity-dependent strategies on regeneration and plasticity after peripheral nerve injuries.
TL;DR: Among the different neurotrophins, BDNF seems a key player in the beneficial effects of activity-dependent therapies after nerve injuries, and also the modulation of the abnormal plasticity of neuronal circuits.
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Differential neuronal vulnerability identifies IGF-2 as a protective factor in ALS
Ilary Allodi,Laura H. Comley,Susanne Nichterwitz,Monica Nizzardo,Chiara Simone,Julio Aguila Benitez,Ming Cao,Stefania Corti,Eva Hedlund +8 more
TL;DR: The studies demonstrate that oculomotor-specific expression can be utilized to identify candidates that protect vulnerable motor neurons from degeneration, and AAV9::IGF-2 delivery to muscles of SOD1G93A ALS mice extended life-span by 10%, while preserving motor neurons and inducing motor axon regeneration.
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In vitro comparison of motor and sensory neuron outgrowth in a 3D collagen matrix.
TL;DR: In this work, an in vitro model based on organotypic cultures of spinal cord slices and dorsal root ganglia explants from P7 rats, embedded in a collagen matrix and cultured under the same conditions is characterized, which can be useful tools to investigate mechanisms for the selective regeneration of sensory and motor neurons.
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Motor neurons with differential vulnerability to degeneration show distinct protein signatures in health and ALS.
Laura H. Comley,Ilary Allodi,Susanne Nichterwitz,Monica Nizzardo,Chiara Simone,Stefania Corti,Eva Hedlund +6 more
TL;DR: It is evident that oculomotor motor neurons have a distinct protein signature compared to vulnerable motor neurons in brain stem and spinal cord, which could in part explain their resistance to degeneration in ALS.