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In Sup Kil
Researcher at Ewha Womans University
Publications - 5
Citations - 802
In Sup Kil is an academic researcher from Ewha Womans University. The author has contributed to research in topics: Sulfiredoxin & Peroxiredoxin. The author has an hindex of 5, co-authored 5 publications receiving 720 citations.
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Journal ArticleDOI
Peroxiredoxin Functions as a Peroxidase and a Regulator and Sensor of Local Peroxides
TL;DR: Peroxiredoxins contain an active site cysteine that is sensitive to oxidation by H2O2, and Regulation of Prx via phosphorylation in response to extracellular signals allows the local accumulation of H2 O2 and thereby enables its messenger function.
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Feedback Control of Adrenal Steroidogenesis via H2O2-Dependent, Reversible Inactivation of Peroxiredoxin III in Mitochondria
TL;DR: The coupling of CYP11B1 activity to PrxIII inactivation provides a feedback regulatory mechanism for steroidogenesis that functions independently of the hypothalamic-pituitary-adrenal axis.
Journal ArticleDOI
Concerted action of sulfiredoxin and peroxiredoxin I protects against alcohol-induced oxidative injury in mouse liver.
Soo Han Bae,Su Haeng Sung,Eun Jung Cho,Se Kyoung Lee,Hye Eun Lee,Hyun Ae Woo,Dae-Yeul Yu,In Sup Kil,Sue Goo Rhee +8 more
TL;DR: It is suggested that Prx I is the most active 2‐Cys Prx in elimination of ROS from the liver of ethanol‐fed mice and that, despite the up‐regulation of SrX expression by ethanol, the capacity of Srx is not sufficient to counteract the hyperoxidation of PrxI that occurs during ROS reduction.
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Induction of sulfiredoxin via an Nrf2-dependent pathway and hyperoxidation of peroxiredoxin III in the lungs of mice exposed to hyperoxia.
TL;DR: It is shown that the expression of Srx at both the mRNA and protein levels is increased markedly in the lungs of mice exposed to hyperoxia, suggesting that, in the absence of a sufficient amount of SrX, sulfinic Prx III is converted to a form that is susceptible to proteolysis.
Journal ArticleDOI
Peroxiredoxin III and Sulfiredoxin Together Protect Mice from Pyrazole-Induced Oxidative Liver Injury
Soo Han Bae,Su Haeng Sung,Hye Eun Lee,Ha Tan Kang,Se Kyoung Lee,Sue Young Oh,Hyun Ae Woo,In Sup Kil,Sue Goo Rhee +8 more
TL;DR: In this article, the mechanisms underlying pyrazole-induced oxidative stress and the protective role of peroxiredoxins (Prxs) and sulfiredoxin (Srx) against such stress were defined.