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Ina van Zantwijk
Researcher at VU University Medical Center
Publications - 10
Citations - 485
Ina van Zantwijk is an academic researcher from VU University Medical Center. The author has contributed to research in topics: Bortezomib & PSMB5. The author has an hindex of 5, co-authored 10 publications receiving 458 citations. Previous affiliations of Ina van Zantwijk include VU University Amsterdam.
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Journal ArticleDOI
Molecular basis of bortezomib resistance: proteasome subunit beta5 (PSMB5) gene mutation and overexpression of PSMB5 protein
Ruud Oerlemans,Niels E. Franke,Yehuda G. Assaraf,Jacqueline Cloos,Ina van Zantwijk,Celia R. Berkers,George L. Scheffer,Kabir Debipersad,Katharina Vojtekova,Clara Lemos,Joost W. van der Heijden,Bauke Ylstra,Godefridus J. Peters,Gertjan L. Kaspers,Ben A. C. Dijkmans,Rik J. Scheper,Gerrit Jansen +16 more
TL;DR: A novel mechanism of bortezomib resistance associated with the selective overexpression of a mutant PSMB5 protein is established and is established in human myelomonocytic THP1 cells by exposure to stepwise increasing concentrations of bortsomib.
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Drug combination testing in acute lymphoblastic leukemia using the MTT assay
Gertjan J.L. Kaspers,Anjo J.P. Veerman,Rob Pieters,Ina van Zantwijk,Karel Hählen,Elisabeth R. van Wering +5 more
TL;DR: The MTT assay can be used to study drug interactions in vitro in ALL samples with marked heterogeneity in drug interactions between patients, between combinations, and between different concentrations within one specific combination.
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Diagnosis of meningeal leukemia using immunoperoxidase methods to demonstrate common acute lymphoblastic leukemia cells in cerebrospinal fluid.
TL;DR: This study focussed on the presence of the common acute lymphoblastic leukemia marker (cALL, determined with the monoclonal antibody J5), which was found to be an invaluable aid to the diagnosis of meningeal leukemia.
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Folates provoke cellular efflux and drug resistance of substrates of the multidrug resistance protein 1 (MRP1)
Jan Hendrik Hooijberg,Gerrit Jansen,Ietje Kathmann,Rob Pieters,A.C. Laan,Ina van Zantwijk,Gertjan J.L. Kaspers,Godefridus J. Peters +7 more
TL;DR: It is demonstrated that increased cellular folate concentrations induce MRP1/ABCC1-related drug efflux and drug resistance, and has important implications in the understanding of the role of MRp1 and its homologs in clinical drug resistance.
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Molecular Mechanisms of Bortezomib Resistance in Acute Lymphoblastic Leukemia Cells in Comparison with Multiple Myeloma Cells.
Niels E. Franke,Ruud Oerlemans,Sonja Zweegman,Ina van Zantwijk,Gertjan J.L. Kaspers,Gerrit Jansen,Jacqueline Cloos +6 more
TL;DR: The results demonstrate that BTZ exhibits potent activity against CEM-ALL and 8226 MM cells, and suggest that MM cells largely retain BTZ sensitivity upon prolonged exposure to BTZ, while in ALL drug resistance phenomena may be more likely to occur.