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Inês Cabrita
Researcher at University of Regensburg
Publications - 23
Citations - 756
Inês Cabrita is an academic researcher from University of Regensburg. The author has contributed to research in topics: Cystic fibrosis transmembrane conductance regulator & Cystic fibrosis. The author has an hindex of 13, co-authored 23 publications receiving 478 citations.
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Journal ArticleDOI
Differential effects of anoctamins on intracellular calcium signals.
Inês Cabrita,Roberta Benedetto,Ana G Fonseca,Podchanart Wanitchakool,Lalida Sirianant,Boris V. Skryabin,Laura K. Schenk,Hermann Pavenstädt,Rainer Schreiber,Karl Kunzelmann +9 more
TL;DR: The data suggest that ANOs affect compartmentalized [Ca2+]i signals, which may explain some of the cellular defects related to ANO mutations.
Journal ArticleDOI
Modulating Ca²⁺ signals: a common theme for TMEM16, Ist2, and TMC.
Karl Kunzelmann,Inês Cabrita,Podchanart Wanitchakool,Jiraporn Ousingsawat,Lalida Sirianant,Roberta Benedetto,Rainer Schreiber +6 more
TL;DR: The role of these proteins in generating compartmentalized Ca2+ signals, which may give a hint as to the broad range of cellular functions of anoctamins, are discussed.
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Contribution of Anoctamins to Cell Survival and Cell Death
TL;DR: It appears reasonable to search for both inhibitors and potent activators of TMEM16 in order to interfere with cancer growth and metastasis, after evidence has been provided for a role of ANO6 (TMEM16F) in regulated cell death.
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TMEM16A is indispensable for basal mucus secretion in airways and intestine
TL;DR: It is concluded that ATP‐dependent mucus secretion in both airways and intestine requires TMEM16A, and the present results may form the basis for a novel, therapeutic approach for the treatment of mucus hypersecretion in inflammatory airway and intestinal disease.
Journal ArticleDOI
TMEM16A in Cystic Fibrosis: Activating or Inhibiting?
Karl Kunzelmann,Jiraporn Ousingsawat,Inês Cabrita,Tereza Doušová,Andrea Bähr,Melanie Janda,Rainer Schreiber,Roberta Benedetto +7 more
TL;DR: Evidence is provided for a crucial role of TMEM16A in fusion of mucus-filled granules with the apical plasma membrane and cellular exocytosis, and taken together, TMEM 16A supports fluid secretion by ciliated airway epithelial cells, but also maintains excessive mucus secretion during inflammatory airway disease.