Andrea Bähr

TL;DR: The first proof-of-principle report on transgenic pigs with β-cell–specific expression of LEA29Y and their successful application as donors in a xenotransplantation model is provided, which may represent a major step toward the development of a novel strategy for pig-to-human islet transplantation without side effects of systemic immunosuppression.

TL;DR: The stable diabetic phenotype and its rescue by insulin treatment make the INSC94Y transgenic pig an attractive model for insulin supplementation and islet transplantation trials, and for studying developmental consequences of maternal diabetes mellitus.

TL;DR: It is suggested that the goblet cell MUC5AC mucin anchors the mucus bundles and thus controls their transport, and is shown by mass spectrometry and immunostaining to have a core made of M UC5B mucin and were coated with MUC7A mucin produced by surfaceGoblet cells.

TL;DR: This review summarizes the most important applications of domestic animal models and emphasizes the new possibilities genetic tailoring of disease models, specifically in pigs, provides.

TL;DR: In this article, human engineered heart tissue (EHT) transplantation represents a potential regenerative strategy for patients with heart failure and has been successful in preclinical models. Clinical...