Hermann Pavenstädt

TL;DR: This review integrates recent physiological and molecular understanding of the role of podocytes during the maintenance and failure of the glomerular filtration barrier with hereditary nephrotic syndromes identified over the last 2 years.

TL;DR: The determinative steps of podocyte differentiation and process formation are studied for the first time using an inducible in vitro model and electrophysiological studies demonstrate that differentiated MPC cells respond to the vasoactive peptide bradykinin by changes in intracellular calcium concentration.

TL;DR: To determine whether early initiation of RRT in patients who are critically ill with AKI reduces 90-day all-cause mortality, a single-center randomized clinical trial of 231 critically ill patients with KDIGO stage 2 found that more patients in the early group recovered renal function by day 90.

TL;DR: It is postulate that constitutive and induced autophagy is a major protective mechanism against podocyte aging and glomerular injury, representing a putative target to ameliorate human glomersular disease and aging-related loss of renal function.

TL;DR: Within the 2-year study period, everolimus slowed the increase in total kidney volume of patients with ADPKD but did not slow the progression of renal impairment [corrected].