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Ingrid Lönnstedt
Researcher at CSL Limited
Publications - 3
Citations - 164
Ingrid Lönnstedt is an academic researcher from CSL Limited. The author has contributed to research in topics: Cluster analysis & Lipid signaling. The author has an hindex of 3, co-authored 3 publications receiving 127 citations.
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Journal ArticleDOI
Comparison of clustering tools in R for medium-sized 10x Genomics single-cell RNA-sequencing data.
Saskia Freytag,Saskia Freytag,Luyi Tian,Luyi Tian,Ingrid Lönnstedt,Milica Ng,Melanie Bahlo,Melanie Bahlo +7 more
TL;DR: It is found that Seurat outperformed other methods, although performance seems to be dependent on many factors, including the complexity of the studied system, and the choice of clustering tool crucially determines interpretation of scRNA-seq data generated by 10x Genomics.
Journal ArticleDOI
Cellular Microenvironment Stiffness Regulates Eicosanoid Production and Signaling Pathways
Asres Berhan,Trudi Harris,Jade Jaffar,Fernando Jativa,Shenna Y. Langenbach,Ingrid Lönnstedt,Monther Alhamdoosh,Milica Ng,Peter Vee Sin Lee,Glen P. Westall,Nicholas J. Wilson,Michael J. Wilson,Alastair G. Stewart +12 more
TL;DR: It is shown that prostaglandin E synthase (PTGES), the final enzyme in the PGE2 biosynthetic pathway is expressed at lower levels in the lungs of IPF patients, revealing an extensive dysregulation of prostanoid biosynthesis and signalling pathways in IPF-derived fibroblasts which are only partially abrogated by culture in soft microenvironments.
Posted ContentDOI
Cluster Headache: Comparing Clustering Tools for 10X Single Cell Sequencing Data
TL;DR: While clustering solutions appeared robust, it was found that solutions produced by different methods have little in common with each other, and all clustering methods failed to replicate cell type assignment generated with supervised labeling approaches.