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Inmaculada Hernandez-Gonzalez
Researcher at Baylor College of Medicine
Publications - 4
Citations - 801
Inmaculada Hernandez-Gonzalez is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Receptor & Ovarian follicle. The author has an hindex of 4, co-authored 4 publications receiving 758 citations.
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Paracrine and autocrine regulation of epidermal growth factor-like factors in cumulus oocyte complexes and granulosa cells: key roles for prostaglandin synthase 2 and progesterone receptor.
TL;DR: In COCs, AREG not only induced genes that impact matrix formation but also genes involved in steroidogenesis and immune cell-like functions (Pdcd1, Runx1, Cd52), and FSH-mediated induction of Areg mRNA via p38MAPK precedes AREG induction of Ptgs2 mRNA via ERK1/2 precedes were recorded.
Journal ArticleDOI
Gene expression profiles of cumulus cell oocyte complexes during ovulation reveal cumulus cells express neuronal and immune-related genes: does this expand their role in the ovulation process?
Inmaculada Hernandez-Gonzalez,Ignacio Gonzalez-Robayna,Masayuki Shimada,Chad M. Wayne,Scott A. Ochsner,Lisa D. White,JoAnne S. Richards +6 more
TL;DR: There is a cumulus cell-specific, terminal differentiation process and the vast number of matrix, neuronal, and especially immune cell-related genes identified by the gene- profiling data of COCs constitutes strong and novel evidence that cumulus cells possess a repertoire of immune functions that could be far greater than simply mediating an inflammatory-like response.
Journal ArticleDOI
Induced expression of pattern recognition receptors in cumulus oocyte complexes: novel evidence for innate immune-like functions during ovulation.
TL;DR: Gene profiling analyses of COCs at selected time intervals during ovulation revealed that many genes associated with immune related surveillance functions were also induced and/or expressed in cumulus cells as well as granulosa cells.
Journal ArticleDOI
Constitutively active FOXO1a and a DNA-binding domain mutant exhibit distinct co-regulatory functions to enhance progesterone receptor A activity
Michael D. Rudd,Ignacio Gonzalez-Robayna,Inmaculada Hernandez-Gonzalez,Nancy L. Weigel,William E. Bingman,Joanne S. Richards +5 more
TL;DR: Results show that FOXOA3 exerts co-regulatory functions independent of DNA binding and that the DNA-binding defective form of FOXO1a is transcriptionally active as a co-Regulator of these nuclear hormone receptors.