Insa S. Schroeder

TL;DR: The results assign both therapeutic and chemopreventive significance to methylation patterns in human HCC and open the possibility of using molecular targets, including those identified in this study, to effectively inhibit HCC development and progression.

TL;DR: The differential induction of NF‐κB and STAT3 point to a distinct role for these transcription factors at different stages of hepatic stem cell differentiation.

TL;DR: Genes regulating microtubule function, including stathmin, Ran, α‐tubulin and hsp27, were all overexpressed in the mammary gland of DMBA‐treated rats, raising the possibility that disruption of microtubules dynamics and abnormal mitosis may be critical events preceding breast cancer development.

TL;DR: NF-κB-mediated regulation of AFP gene expression during liver tumor formation and embryonic development of the liver constitutes a potential novel mechanism used by malignant and fetal hepatocytes to evade immune surveillance.

TL;DR: An efficient antioxidant defense system involving glutathione renders hepatic progenitor cells resistant to TNFα‐mediated apoptosis and acquisition of sensitivity to death stimuli is an implicit feature of the differentiation process.