I
Irakli Dzneladze
Researcher at Ontario Institute for Cancer Research
Publications - 2
Citations - 70
Irakli Dzneladze is an academic researcher from Ontario Institute for Cancer Research. The author has contributed to research in topics: Carcinogenesis & Gene. The author has an hindex of 2, co-authored 2 publications receiving 43 citations.
Papers
More filters
Journal ArticleDOI
Candidate Cancer Driver Mutations in Distal Regulatory Elements and Long-Range Chromatin Interaction Networks.
Helen He Zhu,Helen He Zhu,Liis Uusküla-Reimand,Keren Isaev,Keren Isaev,Lina Wadi,Azad Alizada,Shimin Shuai,Shimin Shuai,Vincent Huang,Dike Aduluso-Nwaobasi,Marta Paczkowska,Diala Abd-Rabbo,Oliver Ocsenas,Oliver Ocsenas,Minggao Liang,J. Drew Thompson,Yao Li,Luyao Ruan,Michal Krassowski,Irakli Dzneladze,Jared T. Simpson,Jared T. Simpson,Mathieu Lupien,Mathieu Lupien,Lincoln D. Stein,Lincoln D. Stein,Paul C. Boutros,Michael D. Wilson,Jüri Reimand,Jüri Reimand +30 more
TL;DR: A driver discovery method is developed and analyzed 120,788 cis-regulatory modules (CRMs) across 1,844 whole tumor genomes from the ICGC-TCGA PCAWG project, finding 30 CRMs with enriched SNVs and indels (FDR < 0.05).
Posted ContentDOI
Candidate cancer driver mutations in superenhancers and long-range chromatin interaction networks
Lina Wadi,Liis Uusküla-Reimand,Keren Isaev,Shimin Shuai,Huang,Minggao Liang,J. Drew Thompson,Yao Li,Luyao Ruan,Marta Paczkowska,Michal Krassowski,Irakli Dzneladze,Ken Kron,Alex Murison,Parisa Mazrooei,Robert G. Bristow,Jared T. Simpson,Mathieu Lupien,Wilson,Lincoln D. Stein,Paul C. Boutros,Jüri Reimand +21 more
TL;DR: This study analyzed 150,000 cis-regulatory regions in 1,844 whole cancer genomes from the ICGC-TCGA PCAWG project and found 41 frequently mutated regulatory elements (FMREs) enriched in non-coding SNVs and indels (FDR<0.05) characterized by aging-associated mutation signatures and frequent structural variants.