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Iris K Cheung
Researcher at Scripps Research Institute
Publications - 2
Citations - 245
Iris K Cheung is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: DNA polymerase mu & Processivity. The author has an hindex of 2, co-authored 2 publications receiving 229 citations.
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Structure and molecular organization of mammalian fatty acid synthase.
Francisco J. Asturias,James Z. Chadick,Iris K Cheung,Helga Stark,Andrzej Witkowski,Anil K. Joshi,Stuart Smith +6 more
TL;DR: The new FAS structure provides a new paradigm for understanding the architecture of FAS and the related modular polyketide synthases and indicates that only limited local rearrangements are required for catalytic interaction among different functional domains.
Journal ArticleDOI
Structure of Saccharomyces cerevisiae DNA polymerase epsilon by cryo-electron microscopy.
Francisco J. Asturias,Iris K Cheung,Nasim Sabouri,Olga Chilkova,Daniel Wepplo,Erik Johansson +5 more
TL;DR: Primer-extension experiments reveal that Pol ε processivity requires a minimum length of primer-template duplex that corresponds to the dimensions of the extended Dpb structure, which might explain how the structure of the enzyme contributes to its intrinsic processivity.