J
James Z. Chadick
Researcher at Scripps Research Institute
Publications - 3
Citations - 334
James Z. Chadick is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: MED1 & General transcription factor. The author has an hindex of 3, co-authored 3 publications receiving 320 citations.
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Journal ArticleDOI
Structure of eukaryotic Mediator complexes
TL;DR: How Mediator interacts with RNA polymerase II is revealed, and it is suggested that regulatory information could be conveyed through changes in Mediator conformation that would influence the transcription initiation process.
Journal ArticleDOI
Structure and molecular organization of mammalian fatty acid synthase.
Francisco J. Asturias,James Z. Chadick,Iris K Cheung,Helga Stark,Andrzej Witkowski,Anil K. Joshi,Stuart Smith +6 more
TL;DR: The new FAS structure provides a new paradigm for understanding the architecture of FAS and the related modular polyketide synthases and indicates that only limited local rearrangements are required for catalytic interaction among different functional domains.
Journal ArticleDOI
Preponderance of Free Mediator in the Yeast Saccharomyces cerevisiae
TL;DR: It is reported that polymerase-free Mediator, isolated early on during a whole-cell extract fractionation protocol, is in fact the most abundant form of the Mediator complex, which would make possible independent recruitment of Mediator and RNA polymerase II to the preinitiation complex.