Iris Valtingojer

TL;DR: A review of the progress and current strategies to directly and indirectly target the YAP1/TAZ protein-protein interaction (PPI) with TEAD1-4 across multiple modalities, with focus on recent small molecules able to selectively bind to TEAD, block its autopalmitoylation and inhibit YAP 1/TZ-dependent transcription in cancer as mentioned in this paper.

TL;DR: In this article , the authors investigated the dependence of malignant mesothelioma on YAP1 signaling to maintain fully established tumors in vivo and showed that downregulation of YAP 1 in a dysfunctional Hippo genetic background results in the inhibition of gene expression, the induction of apoptosis, and the inhibitionof tumor cell growth in vitro.

TL;DR: In this paper , the authors investigated the dependence of malignant mesothelioma on YAP1 signaling to maintain fully established tumors in vivo and showed that downregulation of YAP 1 in a dysfunctional Hippo genetic background results in the inhibition of gene expression, the induction of apoptosis, and the inhibitionof tumor cell growth in vitro.

TL;DR: In this article , the effect of combining TEAD inhibitors with KRASG12C inhibitors in non-small cell lung cancer (NSCLC) tumor models was investigated, and it was shown that the dual inhibition of TEAD and Sotorasib results in the downregulation of MYC and E2F signatures and in the alteration of the G2/M checkpoint.

TL;DR: In this article , the authors investigated the effect of the dual inhibition of MAPK and Hippo-YAP1 signaling in cell lines driven by mutant KRAS and found that dual inhibition was beneficial for some of the tumor cell line tested.