Iris Y. Chen

TL;DR: It is shown that transplanting low doses of undifferentiated mouse embryonic stem cells into the rat striatum results in a proliferation of ES cells into fully differentiated DA neurons that can restore cerebral function and behavior in an animal model of Parkinson's disease.

TL;DR: It is found that intrastriatal administration of the GAPDH inhibitor iodoacetate produces striatal lesions that are significantly attenuated by removal of the corticostriatal glutamatergic input, consistent with an excitotoxic mechanism.

TL;DR: Combining MRI and PET enables monitoring of cell migration and metabolism non-invasively in vivo for extended periods of time, suggesting a prolonged presence of undifferentiated neural stem cells within transplants.

TL;DR: This work has shown that divergent responses to pressure overload in the left and right ventricle could be due to differences in myofiber architecture in the free walls of the LV and RV and that adaptive changes to Pressure overload would be seen in the LV but not the RV.