K
Kwang-Soo Kim
Researcher at Harvard University
Publications - 175
Citations - 12023
Kwang-Soo Kim is an academic researcher from Harvard University. The author has contributed to research in topics: Embryonic stem cell & Dopaminergic. The author has an hindex of 56, co-authored 175 publications receiving 10985 citations. Previous affiliations of Kwang-Soo Kim include McLean Hospital & University of Tennessee.
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Journal ArticleDOI
Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model
Lars Björklund,Rosario Sanchez-Pernaute,Sangmi Chung,Therese Andersson,Therese Andersson,Iris Y. Chen,Kevin St. P. McNaught,Anna-Liisa Brownell,Bruce G. Jenkins,Claes Wahlestedt,Kwang-Soo Kim,Ole Isacson +11 more
TL;DR: It is shown that transplanting low doses of undifferentiated mouse embryonic stem cells into the rat striatum results in a proliferation of ES cells into fully differentiated DA neurons that can restore cerebral function and behavior in an animal model of Parkinson's disease.
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A vector-free microfluidic platform for intracellular delivery
Armon Sharei,Janeta Zoldan,Andrea Adamo,Woo Young Sim,Nahyun Cho,Emily L. Jackson,Shirley Mao,Sabine Schneider,Min-Joon Han,Abigail K. R. Lytton-Jean,Pamela Basto,Siddharth Jhunjhunwala,Jungmin Lee,Daniel A. Heller,Jeon Woong Kang,George C. Hartoularos,Kwang-Soo Kim,Daniel G. Anderson,Robert Langer,Klavs F. Jensen +19 more
TL;DR: A microfluidic approach to delivery in which cells are mechanically deformed as they pass through a constriction 30–80% smaller than the cell diameter results in the formation of transient holes that enable the diffusion of material from the surrounding buffer into the cytosol.
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Hemangioblastic derivatives from human induced pluripotent stem cells exhibit limited expansion and early senescence.
Qiang Feng,Shi-Jiang Lu,Irina Klimanskaya,Ignatius Gomes,Dohoon Kim,Young Gie Chung,George R. Honig,Kwang-Soo Kim,Robert Lanza +8 more
TL;DR: It is demonstrated here that hiPSCs are capable of generating hemangioblasts/blast cells (BCs), endothelial cells, and hematopoietic cells with phenotypic and morphologic characteristics similar to those derived from hESCs, but with a dramatic decreased efficiency.
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Depletion of human micro-RNA miR-125b reveals that it is critical for the proliferation of differentiated cells but not for the down-regulation of putative targets during differentiation.
TL;DR: It is reported that small interfering RNA against the loop region of a micro-RNA precursor can be used to deplete the micro- RNAs, revealing the importance of micro- RNA depletion strategies for directly determining micro-RNAs function in vivo.
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LRRK2 regulates synaptic vesicle endocytosis.
Narae Shin,Hyerhan Jeong,Jungsun Kwon,Hye Young Heo,Jung June Kwon,Hye Jin Yun,Cy Hyun Kim,Baek Soo Han,Youren Tong,Jie Shen,Taku Hatano,Nobutaka Hattori,Kwang-Soo Kim,Sunghoe Chang,Wongi Seol +14 more
TL;DR: It is proposed that LRRK2, in conjunction with its interaction with Rab5b, plays an important role in synaptic function by modulating the endocytosis of synaptic vesicles.