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Isaac H. Chu
Researcher at University of California, Irvine
Publications - 2
Citations - 107
Isaac H. Chu is an academic researcher from University of California, Irvine. The author has contributed to research in topics: FADD & Death domain. The author has an hindex of 2, co-authored 2 publications receiving 107 citations.
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The requirements for Fas-associated death domain signaling in mature T cell activation and survival.
TL;DR: Results show that, in a highly regulated fashion, FADD, and most likely caspases, can transduce either a signal for survival or one that leads directly to apoptosis and that the balance between these opposing outcomes is crucial to adaptive immunity.
Journal ArticleDOI
Cutting Edge: FADD Is Not Required for Antigen Receptor-Mediated NF-κB Activation
Adrian F. Arechiga,Bryan D. Bell,Jennifer C. Solomon,Isaac H. Chu,Claire L. Dubois,Brian E. Hall,Thaddeus C. George,David Coder,Craig M. Walsh +8 more
TL;DR: Pretreatment with benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone, a potent caspase inhibitor, failed to impede canonical NF-κB signaling, suggesting an alternative route by which this adaptor promotes the clonal expansion of T cells.