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Isabel Quiros-Gonzalez
Researcher at University of Cambridge
Publications - 28
Citations - 691
Isabel Quiros-Gonzalez is an academic researcher from University of Cambridge. The author has contributed to research in topics: Melatonin & Medicine. The author has an hindex of 12, co-authored 22 publications receiving 539 citations. Previous affiliations of Isabel Quiros-Gonzalez include Wellcome Trust Sanger Institute & University of Oviedo.
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Melatonin uptake through glucose transporters: a new target for melatonin inhibition of cancer.
David Hevia,Pedro Gonzalez-Menendez,Isabel Quiros-Gonzalez,Ana Miar,Aida Rodriguez-Garcia,Dun Xian Tan,Russel J. Reiter,Juan C. Mayo,Rosa M. Sainz +8 more
TL;DR: It is demonstrated that members of the SLC2/GLUT family glucose transporters have a central role in melatonin uptake and is the first time that a facilitated transport of melatonin is suggested.
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Vitamin B12–dependent taurine synthesis regulates growth and bone mass
Pablo Román-García,Isabel Quiros-Gonzalez,Lynda Mottram,Liesbet Lieben,Kunal Sharan,Arporn Wangwiwatsin,Jose M. C. Tubio,Kirsty E. Lewis,Debbie Wilkinson,Balaji Santhanam,Nazan Sarper,Simon Clare,George S. Vassiliou,Vidya Velagapudi,Gordon Dougan,Vijay K. Yadav +15 more
TL;DR: Vitamin B12 is identified as an essential vitamin that positively regulates postweaning growth and bone formation through taurine synthesis and suggests potential therapies to increase bone mass.
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Evaluation of Precision in Optoacoustic Tomography for Preclinical Imaging in Living Subjects
James Joseph,Michal R. Tomaszewski,Isabel Quiros-Gonzalez,Judith Weber,Joanna Brunker,Sarah E. Bohndiek +5 more
TL;DR: Optoacoustic tomography data acquired with the small-animal OT system were highly repeatable and reproducible across subjects and over time, and longitudinal OT studies may be performed with high confidence when the standard operating procedure is followed.
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Phenotypic changes caused by melatonin increased sensitivity of prostate cancer cells to cytokine‐induced apoptosis
Aida Rodriguez-Garcia,Juan C. Mayo,David Hevia,Isabel Quiros-Gonzalez,Maria Navarro,Rosa M. Sainz +5 more
TL;DR: In this paper, the role of melatonin in drug-induced apoptosis was studied after acute treatments and showed that melatonin is a good inhibitor of the proliferation of prostate cancer cells, promoting phenotypic changes that do not increase survival mechanisms and make cells more sensitive to cytokines such as TNF-alpha or TRAIL.
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IGFBP3 and MAPK/ERK signaling mediates melatonin-induced antitumor activity in prostate cancer.
Juan C. Mayo,David Hevia,Isabel Quiros-Gonzalez,Aida Rodriguez-Garcia,Pedro Gonzalez-Menendez,Vanesa Cepas,Ivan Gonzalez-Pola,Rosa M. Sainz +7 more
TL;DR: Melatonin blocked nuclear translocation of androgen receptor (AR), thus confirming anti‐androgenic actions of the indole, and melatonin prolonged the survival of TRAMP mice by 33% when given at the beginning or at advances stages of the tumor.