Isabella M. Guimaraes

TL;DR: Synthesis of cholinergic neurons located in the basal forebrain, including the neurons that form the nucleus basalis of Meynert, are severely lost in Alzheimer’s disease, and drugs that act on the choline system represent a promising option to treat AD patients.

TL;DR: It is demonstrated that the mGluR5 PAM, CDPPB, is a potent neuroprotective drug, in vitro and in vivo, capable of delaying HD-related symptoms.

TL;DR: The data suggest that mutant huntingtin protein and mGluR5 exhibit a functional interaction that may be important for HD-mediated alterations in locomotor behavior and the development of intranuclear inclusions.

TL;DR: St stereotactic microinfusions of the mGluR5 antagonist, MPEP, into specific brain regions and submitted mice to the open field and rotarod apparatus suggest that not only primarily motor neural substrates, but also limbic and sensory structures are involved in mGLUR5-mediated motor behavior.

TL;DR: Although the data published so far strongly indicate that mGluR5 plays a major role in HD-associated neurodegeneration, htt aggregation and motor symptoms, it is not clear whether mGLUR5 stimulation can diminish or intensify neuronal cell loss and HD progression.