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Isabelle Desvignes
Researcher at University of Montpellier
Publications - 10
Citations - 174
Isabelle Desvignes is an academic researcher from University of Montpellier. The author has contributed to research in topics: Capillary electrophoresis & Taylor dispersion. The author has an hindex of 7, co-authored 10 publications receiving 162 citations. Previous affiliations of Isabelle Desvignes include Centre national de la recherche scientifique & École nationale supérieure de chimie de Montpellier.
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Dendrigraft Poly-l-lysine: A Non-Immunogenic Synthetic Carrier for Antibody Production
Bernard Romestand,Jean-Luc Rolland,Auguste Commeyras,Gaëlle Coussot,Isabelle Desvignes,Robert Pascal,Odile Vandenabeele-Trambouze +6 more
TL;DR: An easily synthesized DendriGraft poly-lysine DGL-G3 (third generation) was shown to act as an efficient carrier for raising antibodies directed against small molecules, and a second immunization improved the production of specific hapten-directed antibodies, which demonstrates the utility of DGL -G3 as a carrier for theProduction of highly specific antibody against haptens.
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Colorimetric quantification of amino groups in linear and dendritic structures
Gaëlle Coussot,Edith Nicol,Auguste Commeyras,Isabelle Desvignes,Robert Pascal,Odile Vandenabeele-Trambouze +5 more
TL;DR: The developed method using Coomassie blue binding can be used for the quantification of cationic groups in a macromolecule grafted onto a solid surface and it is demonstrated that one Coomassi blue molecule interacts with only one single protonated group.
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Size-based characterization of nanoparticle mixtures by the inline coupling of capillary electrophoresis to Taylor dispersion analysis.
TL;DR: The remarkable separating performances of CE were complemented with the absolute size-based determination provided by Taylor dispersion analysis (TDA) for the characterization of nanoparticle mixtures for industrial/research applications or regulatory purposes.
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Investigation of neutron radiation effects on polyclonal antibodies (IgG) and fluorescein dye for astrobiological applications.
A. Le Postollec,Gaëlle Coussot,Mickael Baqué,Sebastien Incerti,Isabelle Desvignes,Philippe Moretto,Michel Dobrijevic,O. Vandenabeele-Trambouze +7 more
TL;DR: Antibodies and fluorescent dyes, freeze-dried and in buffer solution, were irradiated with 0.6 MeV and 6 MeV neutrons and sample analyses demonstrated that, in the conditions tested, antibody recognition capability and fluorescence dye intensity are not affected by the neutrons.
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Biochip for astrobiological applications: Investigation of low energy protons effects on antibody performances
Mickael Baqué,A. Le Postollec,A. Le Postollec,Gaëlle Coussot,Thomas Moreau,Isabelle Desvignes,Sebastien Incerti,Philippe Moretto,Michel Dobrijevic,Michel Dobrijevic,Odile Vandenabeele-Trambouze +10 more
TL;DR: In this paper, the effect of low energy protons (2 MeV) on antibody performances with fluences levels much greater than expected for a typical mission to Mars was investigated and it was shown that these particles do not alter significantly the antibody recognition capability for both free and grafted freeze-dried antibodies.