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Isabelle Godin
Researcher at Institut Gustave Roussy
Publications - 69
Citations - 7633
Isabelle Godin is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 36, co-authored 69 publications receiving 7213 citations. Previous affiliations of Isabelle Godin include Collège de France & Université Paris-Saclay.
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Journal ArticleDOI
Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain
TL;DR: The hypothesis that terminally differentiated brain parenchymal microglia are derived from cells originating from the yolk sac whose progeny actively proliferates in situ during development is supported.
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Lymphoid potential, probed before circulation in mouse, is restricted to caudal intraembryonic splanchnopleura.
TL;DR: Yolk sacs from the same embryos are unable to generate lymphoid progeny and have a reduced potential for myeloid differentiation and maintenance, so if isolated before circulation, the yolk sac does not produce multipotent precursors and therefore does not contribute to definitive hemopoiesis in the mouse.
Journal ArticleDOI
Ontogeny of the Hematopoietic System
Ana Cumano,Isabelle Godin +1 more
TL;DR: The experimental evidence that argues for the extrinsic origin of HSCs and the potential locations where HSC generation might occur are discussed and the identification of the cellular components playing a role in the generation process will be important in understanding the molecular mechanisms involved in HSC production from undifferentiated mesoderm.
Journal ArticleDOI
Effects of the Steel Gene Product on Mouse Primordial Germ Cells in Culture
Isabelle Godin,Richard W Deed,Jeff Cooke,Krisztina M. Zsebo,T Michael Dexter,Christopher Wylie +5 more
TL;DR: It is suggested that SCF in vivo is an essential requirement for PGC survival, and this demon-strates the control of the early germ-line population by a specific trophic factor.
Journal ArticleDOI
Para-aortic splanchnopleura from early mouse embryos contains B1a cell progenitors
Isabelle Godin,Juan A. García-Porrero,Antonio Coutinho,Françoise Dieterlen-Lièvre,Miguel Marcos,Miguel Marcos +5 more
TL;DR: The haematogenic capacity revealed in these experiments is present in a previously unrecognized site, the earliest described in the embryo, 12 hours before fetal liver colonization.