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Ivan Khvorostov
Researcher at Max Planck Society
Publications - 2
Citations - 559
Ivan Khvorostov is an academic researcher from Max Planck Society. The author has contributed to research in topics: Mutation & Processivity. The author has an hindex of 2, co-authored 2 publications receiving 538 citations.
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Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production
Aleksandra Trifunovic,Anna Hansson,Anna Wredenberg,Anja T. Rovio,Eric Dufour,Ivan Khvorostov,Johannes N. Spelbrink,Rolf Wibom,Howard T. Jacobs,Nils-Göran Larsson +9 more
TL;DR: The premature aging phenotypes in mt DNA mutator mice are thus not generated by a vicious cycle of massively increased oxidative stress accompanied by exponential accumulation of mtDNA mutations, and it is proposed that respiratory chain dysfunction per se is the primary inducer of premature aging in mtDNA mutATOR mice.
Journal ArticleDOI
Sequence-specific stalling of DNA polymerase γ and the effects of mutations causing progressive ophthalmoplegia
Neli Atanassova,Javier Miralles Fusté,Sjoerd Wanrooij,Bertil Macao,Steffi Goffart,Stefan Bäckström,Géraldine Farge,Ivan Khvorostov,Nils-Göran Larsson,Johannes N. Spelbrink,Maria Falkenberg +10 more
TL;DR: A novel explanation for the dominant mtDNA replication phenotypes seen in patients harboring the Y955C mutation is provided, including the existence of site-specific stalling, which may also explain why mutations that disturb dATP pools can be especially deleterious for mtDNA synthesis.