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Iván L. Csanaky
Researcher at University of Kansas
Publications - 35
Citations - 1737
Iván L. Csanaky is an academic researcher from University of Kansas. The author has contributed to research in topics: Bile acid & Arsenite. The author has an hindex of 20, co-authored 35 publications receiving 1547 citations. Previous affiliations of Iván L. Csanaky include University of Missouri–Kansas City & University of Pécs.
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Journal ArticleDOI
Quantitative-profiling of bile acids and their conjugates in mouse liver, bile, plasma, and urine using LC-MS/MS
TL;DR: A reliable and simple LC-MS/MS method to quantify major BAs and their metabolites was developed and applied to quantify BAs in mouse tissues and fluids.
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Characterization of Organic Anion Transporting Polypeptide 1b2-null Mice: Essential Role in Hepatic Uptake/Toxicity of Phalloidin and Microcystin-LR
Hong Lu,Supratim Choudhuri,Kenichiro Ogura,Iván L. Csanaky,Xiaohong Lei,Xingguo Cheng,Peizhen Song,Curtis D. Klaassen +7 more
TL;DR: Oatp1b2-null mice display altered basic physiology and markedly decreased hepatic uptake/toxicity of phalloidin and microcystin-LR, a blue-green algae toxin, and are useful in elucidating the role of Oatp 1b2 and its human orthologs OATP1B1/1B3 in hepatics uptake and systemic disposition of toxic chemicals and therapeutic drugs.
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Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co–therapy
Feng Li,Jie Lu,Jie Cheng,Laiyou Wang,Laiyou Wang,Tsutomu Matsubara,Iván L. Csanaky,Curtis D. Klaassen,Frank J. Gonzalez,Xiaochao Ma +9 more
TL;DR: Using a pregnane X receptor-humanized mouse model, it is found that co-treatment with RIF and INH causes accumulation of the endogenous hepatotoxin protoporphyrin IX in the liver through PXR-mediated alteration of the heme biosynthesis pathway.
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Biliary and Urinary Excretion of Inorganic Arsenic: Monomethylarsonous Acid as a Major Biliary Metabolite in Rats
TL;DR: The inorganic arsenicals investigated are transported into bile exclusively in trivalent forms, namely as AsIII and MMAsIII, but are excreted in urine in both tri- and pentavalent forms.
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Simultaneous characterization of bile acids and their sulfate metabolites in mouse liver, plasma, bile, and urine using LC-MS/MS
TL;DR: A simple, sensitive, and validated LC-MS/MS method was applied to simultaneously quantify BAs and BA-sulfates in both male and female mouse tissues and fluids, providing strong evidence that sulfation is a minor metabolic pathway of BA elimination and detoxification in mice.