Ivanka Markovic

TL;DR: It is demonstrated that ribavirin‐triggered Akt/mTORC1‐dependent autophagy counteracts apoptotic death of glioma cells, indicating autophile suppression as a plausible therapeutic strategy for sensitization of cancer cells to IMPDH inhibition.

TL;DR: The results suggest that hypoxanthine uptake was Na+-independent, which means that transport system on the basolateral membrane can mediate the transport in both directions, and it seems that the transport of purine nucleobases through basol lateral membrane is mediated via a common transporter which is different from the nucleoside transporters.

TL;DR: The cytotoxic effect of two isomeric quinoline‐based complexes is predominantly mediated through the induction of apoptotic cell death in HL‐60 cell line, comparable to the activity of cisplatin, in all cell lines investigated.

TL;DR: The single pass paired dilution technique was used to measure the uptake of nucleosides across the basolateral face of the isolated in situ perfused sheep choroid plexus and it would appear that the uptake for adenosine by the CP is governed by the rate of cellular metabolism and not by the rates of transport into the cells of the choroids plexu whereas for guanosine and thymidine, transport is of greater importance.

TL;DR: N-Butyl ester 1e induced production of reactive oxygen species and caused an oxidative-stress-derived accumulation of glioma cells in the G0/G1 phase of the cell cycle, suggesting that apoptosis induction plays an important role in the novel compounds' antiglioma action.